	US 12,111,285 B2
	Mass spectrometry method and mass spectrometer
Hidenori Takahashi, Kyoto (JP); Sadanori Sekiya, Kyoto (JP); and Shosei Yamauchi, Kyoto (JP)
Assigned to SHIMADZU CORPORATION, Kyoto (JP)
Appl. No. 17/767,946
Filed by SHIMADZU CORPORATION, Kyoto (JP)
PCT Filed Nov. 11, 2019, PCT No. PCT/JP2019/044183 § 371(c)(1), (2) Date Apr. 11, 2022, PCT Pub. No. WO2021/095105, PCT Pub. Date May 20, 2021.
Prior Publication US 2024/0102962 A1, Mar. 28, 2024
Int. Cl. G01N 27/62 (2021.01); H01J 49/26 (2006.01)

CPC G01N 27/62 (2013.01) [H01J 49/26 (2013.01)]

12 Claims

1. A mass spectrometry method comprising steps of:

acquiring first product ion spectrum data by dissociating a precursor ion derived from a sample component by collision between the precursor ion and an inert gas molecule to generate product ions, and detecting the product ions after separating the product ions according to a mass-to-charge ratio;

acquiring second product ion spectrum data by dissociating the precursor ion by a reaction of the precursor ion with hydrogen radicals to generate product ions, and detecting the product ions after separating the product ions according to a mass-to-charge ratio; and

extracting a set of product ions having a predetermined mass difference in the first product ion spectrum data and the second product ion spectrum data.