US 12,111,280 B2
Biosensing systems having biosensors coated with co-polymers and uses thereof
Fei Yu, Hangzhou (CN)
Assigned to MICROTECH MEDICAL (HANGZHOU) CO., LTD., Hangzhou (CN)
Appl. No. 16/638,870
Filed by MICROTECH MEDICAL (HANGZHOU) CO., LTD., Hangzhou (CN)
PCT Filed Apr. 30, 2019, PCT No. PCT/CN2019/085200
§ 371(c)(1), (2) Date Feb. 13, 2020,
PCT Pub. No. WO2020/220263, PCT Pub. Date Nov. 5, 2020.
Prior Publication US 2021/0255133 A1, Aug. 19, 2021
Int. Cl. G01N 27/327 (2006.01); C08G 18/40 (2006.01); C08G 18/44 (2006.01); C08G 18/50 (2006.01); C08G 18/61 (2006.01); C08G 18/62 (2006.01); G01N 27/30 (2006.01); G01N 33/487 (2006.01)
CPC G01N 27/3272 (2013.01) [G01N 33/487 (2013.01)] 32 Claims
OG exemplary drawing
 
1. A biosensing system, comprising:
(1) a biosensor, comprising:
a substrate,
a working electrode on top of the substrate,
a detection layer on top of the working electrode,
a biocompatible membrane on top of the detection layer,
a blank electrode, wherein the blank electrode is substantially same as the working electrode and covered directly by the biocompatible membrane,
a reference electrode, and
a counter electrode;
(2) a DC power supply;
(3) a current measuring unit;
(4) an AC impedance measuring unit;
(5) a circuit switch;
(6) a control unit; and
(7) a data processing unit, wherein the biosensor further comprises an adhesive layer between the detection layer and the biocompatible membrane on top of the working electrode and between the biocompatible membrane and the blank electrode, and wherein the adhesive layer comprises a polymer comprising a first monomer comprising at least two amine moieties crosslinked with a second monomer comprising at least two formyl moieties.