CPC C23C 14/205 (2013.01) [A61B 5/14532 (2013.01); A61B 5/14865 (2013.01); B23K 26/36 (2013.01); B41M 1/06 (2013.01); B41M 1/10 (2013.01); B41M 1/12 (2013.01); B41M 5/0047 (2013.01); C23C 14/14 (2013.01); C23C 14/34 (2013.01); C23C 14/562 (2013.01); C23C 14/5813 (2013.01); C23C 14/5873 (2013.01); G01N 27/327 (2013.01); G01N 27/3271 (2013.01); G01N 27/3273 (2013.01); G01N 27/3277 (2013.01); G01N 27/4115 (2013.01); A61B 5/1486 (2013.01); A61B 2562/0209 (2013.01); A61B 2562/125 (2013.01); C12Q 1/006 (2013.01); G01N 27/40 (2013.01)] | 20 Claims |
1. A method for fabricating analyte sensors in a roll-to-roll process, the method comprising:
providing a roll of a polyester substrate having a first side sputtered with a layer of platinum, wherein the platinum is in direct contact with the polyester substrate;
feeding the polyester substrate from the roll to an electrode patterning stage;
patterning the layer of platinum to form working electrodes and reference electrodes;
feeding the polyester substrate to an insulation stage; forming an insulating dielectric layer over the polyester substrate;
feeding the polyester substrate to an insulation curing stage;
curing the insulating dielectric layer; feeding the polyester substrate to an ink printing stage;
depositing silver/silver chloride ink over the reference electrodes;
feeding the polyester substrate to a drying stage;
drying the silver/silver chloride ink;
feeding the polyester substrate to a protection stage;
depositing a protection material over the working electrodes and reference electrodes;
feeding the polyester substrate to a protection layer curing stage;
curing the protection material to form a protection layer over the working electrodes and reference electrodes;
feeding the polyester substrate to a punching stage;
punching the polyester substrate to form ribbons, wherein each ribbon is connected to a remaining polyester substrate web by a tab, and wherein each sensor includes one of the working electrodes and one of the reference electrodes;
feeding the remaining polyester substrate to an enzyme deposition stage;
depositing an enzyme layer over the working electrodes;
feeding the remaining polyester substrate to an enzyme curing stage;
curing the enzyme layer;
feeding the remaining polyester substrate to a membrane formation stage; and
coating the working electrodes with a glucose limiting membrane.
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