US 12,110,562 B2
Compositions and methods for predicting and promoting weight loss
Mads Fiil Hjorth, Rødovre (DK); Arne Vernon Astrup, Klampenborg (DK); and Yishai Zohar, Brookline, MA (US)
Assigned to University of Copenhagen, Copenhagen (DK)
Filed by University of Copenhagen, Copenhagen (DK)
Filed on May 30, 2018, as Appl. No. 15/992,496.
Claims priority of provisional application 62/646,884, filed on Mar. 22, 2018.
Claims priority of provisional application 62/594,172, filed on Dec. 4, 2017.
Claims priority of provisional application 62/550,925, filed on Aug. 28, 2017.
Claims priority of provisional application 62/513,743, filed on Jun. 1, 2017.
Prior Publication US 2019/0062811 A1, Feb. 28, 2019
Int. Cl. C12Q 1/689 (2018.01); A23L 33/00 (2016.01); A23L 33/21 (2016.01); A61K 35/74 (2015.01); A61K 35/741 (2015.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01)
CPC C12Q 1/689 (2013.01) [A23L 33/21 (2016.08); A23L 33/30 (2016.08); A23L 33/40 (2016.08); A61K 35/74 (2013.01); A61K 35/741 (2013.01); A61P 3/04 (2018.01); A61P 3/06 (2018.01); A23V 2002/00 (2013.01); A23V 2200/332 (2013.01)] 3 Claims
OG exemplary drawing
 
1. A method of promoting weight loss in a patient wherein the patient has been identified as having at least one of: (a) a gut microbiota with a relative abundance of log 10 (Prevotella spp.) of greater than −3, (b) a gut microbiota with a relative abundance of log 10 (Prevotella spp./Bacteroides spp.) of greater than −2, (c) a gut microbiota with a relative abundance of Log 10 (Prevotella spp./Bacteroidetes all) of greater than −2, and (d) a gut microbiota with a relative abundance of Log 10(Bacteroidetes all/Bacteroides spp.) of greater than 0, comprising the steps of;
(a) determining the patient's fasting plasma glucose (FPG) and fasting insulin level (FI); and
(b) administering to the patient a predetermined diet, wherein
(i) the patient's FPG is less than about 90 mg/dL, the patient's FI is below about 9.5 uU/mL and the predetermined diet is Diet 1;
(ii) the patient's FPG is less than about 90 mg/dL, the patient's FI is above about 13 uU/mL, and the predetermined diet is Diet 2;
(iii) the patient's FPG is between about 90 and 100 mg/dL, the patient's FI is above about 13 uU/mL and the predetermined diet is Diet 4;
(iv) the patient's FPG is between about 100 and 115 mg/dL, the patient's FI is below about 9.5 uU/mL and the predetermined diet is Diet 5;
(v) the patient's FPG is between about 100 and 115 mg/dL, the patient's FI is above about 13 uU/mL and the predetermined diet is Diet 6;
(vi) vi the patient's FPG is between about 115 and 125 mg/dL, the patient's FI is below about 9.5 uU/mL and the predetermined diet is Diet 7;
(vii) vii the patient's FPG is between about 115 and 125 mg/dL, the patient's FI is above about 13 uU/mL and the predetermined diet is Diet 8;
(viii) the patient's FPG is greater than about 125 mg/dL, the patient's FI is below about 9.5 uU/mL and the predetermined diet is Diet 9;
(ix) the patient's FPG is greater than about 125 mg/dL, the patient's FI is above about 13 uU/mL and the predetermined diet is Diet 10;
(x) the patient's FPG is less than about 90 mg/dL, the patient's FI is between about 9.5 to about 13 uU/mL, and the predetermined diet is Diet 1 or Diet 2;
(xi) the patient's FPG is between about 90 and 100 mg/dL, the patient's FI is between about 9.5 to about 13 uU/mL, and the predetermined diet is Diet 4;
(xii) the patient's FPG is between about 100 and 115 mg/dL, the patient's FI is between about 9.5 to about 13 uU/mL, and the predetermined diet is Diet 5 or Diet 6;
(xiii) the patient's FPG is between about 115 and 125 mg/dL, the patient's FI is between about 9.5 to about 13 uU/mL, and the predetermined diet is Diet 7 or Diet 8; or
(xiv) the patient's FPG is greater than about 125 mg/dL, the patient's FI is between about 9.5 to about 13 uU/mL, and the predetermined diet is Diet 9 or Diet 10;
wherein diets 1, 2 and 4-10 are defined in the table below:
 
 
 
Diet 1 Carbohydrate: 52-56%
 
 
Protein: 19-23%
 
 
Fat: 23-27%
 
 
Fiber: >30 g/10 MJ
 
 
Added sugar: <15E%
 
Diet 2 Carbohydrate: 28-32%
 
 
Protein: 23-27%
 
 
Fat: 43-47%
 
 
Fiber: >20 g/10 MJ
 
 
Added sugar: <5E%
 
Diet 4 Carbohydrate: 38-42%
 
 
Protein: 23-27%
 
 
Fat: 33-37%
 
 
Fiber: >25 g/10 MJ
 
 
Added sugar: <10E%
 
Diet 5 Carbohydrate: 42-46%
 
 
Protein: 19-23%
 
 
Fat: 33-37%
 
 
Fiber: >30 g/10 MJ
 
 
Added sugar: <15E%
 
Diet 6 Carbohydrate: 35-39%
 
 
Protein: 23-27%
 
 
Fat: 36-40%
 
 
Fiber: >25 g/10 MJ
 
 
Added sugar: <10E%
 
Diet 7 Carbohydrate: 37-41%
 
 
Protein: 19-23%
 
 
Fat: 38-42%
 
 
Fiber: >30 g/10 MJ
 
 
Added sugar: <10E%
 
Diet 8 Carbohydrate: 31-35%
 
 
Protein: 23-27%
 
 
Fat: 40-44%
 
 
Fiber: >20 g/10 MJ
 
 
Added sugar: <5E%
 
Diet 9 Carbohydrate: 32-36%
 
 
Protein: 19-23%
 
 
Fat: 43-47%
 
 
Fiber: >25 g/10 MJ
 
 
Added sugar: <5E%
 
Diet 10 Carbohydrate: 28-32%
 
 
Protein: 23-27%
 
 
Fat: 43-47%
 
 
Fiber: >20 g/10 MJ
 
 
Added sugar: <5E%