US 12,110,482 B2
Instruments for processing cells
Weston Blaine Griffin, Niskayuna, NY (US); Mark Robert Timmins, Marlborough, MA (US); Dan Harris, Merrimack, NH (US); Spencer Lovette, Merrimack, NH (US); Jim Dowling, Merrimack, NH (US); Dan O'Sullivan, Hollis, NH (US); and David Robinson, Burlington, MA (US)
Assigned to Global Life Sciences Solutions USA LLC, Marlborough, MA (US)
Filed by Global Life Sciences Solutions USA LLC, Marlborough, MA (US)
Filed on Oct. 24, 2022, as Appl. No. 18/049,180.
Application 18/049,180 is a continuation of application No. 16/065,642, granted, now 11,512,277, previously published as PCT/EP2016/082401, filed on Dec. 22, 2016.
Claims priority of provisional application 62/346,009, filed on Jun. 6, 2016.
Claims priority of provisional application 62/270,915, filed on Dec. 22, 2015.
Prior Publication US 2023/0060399 A1, Mar. 2, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C12M 1/36 (2006.01); C12M 1/00 (2006.01); C12M 1/34 (2006.01)
CPC C12M 41/48 (2013.01) [C12M 23/00 (2013.01); C12M 23/28 (2013.01); C12M 23/40 (2013.01); C12M 29/00 (2013.01); C12M 29/14 (2013.01); C12M 41/00 (2013.01); C12M 41/44 (2013.01); C12M 47/02 (2013.01); C12M 47/12 (2013.01)] 12 Claims
OG exemplary drawing
 
1. An instrument for processing cells including culturing, concentrating or washing said cells that is adaptable to receive a disposable processing kit comprising a fluid circuit including a fluid reservoir and at least one fluid path, the instrument comprising:
a housing including at least one pump that is adaptable to receive the disposable processing kit and provide fluid flow, by the at least one fluid pump, to the at least one fluid path;
a mechanism configured for determining a quantity or change in quantity of a fluid in the reservoir, and
a controller programmed to control said at least one fluid pump and operable to perform a fault determination process, which includes steps of:
determining an expected flow rate of said at least one fluid pump calculated from the speed of said at least one fluid pump;
comparing the expected flow rate with the change in quantity of the fluid in the reservoir; and
producing an error or fault condition based at least in part on a determination that said comparison produces a difference above a predetermined value.