US 12,110,481 B2
Method and system for creating reconfigurable bio-processing workflows
Victor Jose, Bangalore (IN); Andreas Axen, Uppsala (SE); Klaus Gebauer, Uppsala (SE); Veena B N Rao, Bangalore (IN); Patric Fricking, Uppsala (SE); and Hanish Lakhani, Bangalore (IN)
Assigned to Cytiva Sweden AB, Uppsala (SE)
Appl. No. 16/607,516
Filed by Cytiva Sweden AB, Uppsala (SE)
PCT Filed Apr. 18, 2018, PCT No. PCT/EP2018/059809
§ 371(c)(1), (2) Date Oct. 23, 2019,
PCT Pub. No. WO2018/197273, PCT Pub. Date Nov. 1, 2018.
Claims priority of application No. 201741015122 (IN), filed on Apr. 28, 2017.
Prior Publication US 2020/0131467 A1, Apr. 30, 2020
Int. Cl. C12M 1/36 (2006.01); C12M 1/00 (2006.01); G16H 10/40 (2018.01)
CPC C12M 41/48 (2013.01) [C12M 23/26 (2013.01); C12M 23/28 (2013.01); G16H 10/40 (2018.01)] 10 Claims
OG exemplary drawing
 
1. A bio-processing system, comprising:
one or more bio-processing units comprising a bioreactor for cell cultivation, configured to perform at least one bio-processing operation;
one or more process supporting devices, selected from a pump, a weighing scale, a flow restriction clamp, a temperature management device, or a combination thereof, operatively coupled to the one or more bio-processing units, wherein the one or more process supporting devices are configured to aid the one or more bio-processing units in performing the at least one bio-processing operation;
one or more sensors operatively coupled to at least one of the one or more bio-processing units and the one or more process supporting devices;
a bio-processing workflow controller wirelessly coupled to at least one of the one or more bio-processing units, the one or more process supporting devices, and the one or more sensors, wherein the bio-processing workflow controller comprises:
a processor configured to create a reconfigurable bio-processing workflow, and wherein the reconfigurable bio-processing workflow is representative of an arrangement of one or more of the one or more bio-processing units, the one or more process supporting devices, and the one or more sensors to perform the at least one bio-processing operation; and
a data repository comprising a listing of the one or more bio-processing units, the one or more process supporting devices, the one or more sensors, one or more process steps, one or more types of bio-processing workflows, or combinations thereof; and
one or more flexible fluid coupling tubes configured to facilitate fluid communication between the one or more bio-processing units, the one or more process supporting devices, and the one or more sensors.