US 12,110,473 B2
Free-polyunsaturated-fatty-acid-containing composition and method for manufacturing same
Hideaki Yamaguchi, Tokyo (JP); Nobushige Doisaki, Tsukuba (JP); Seizo Sato, Tokyo (JP); and Yuhei Kosuge, Tokyo (JP)
Assigned to NISSUI CORPORATION, Tokyo (JP)
Filed by Nissui Corporation, Tokyo (JP)
Filed on Oct. 26, 2021, as Appl. No. 17/511,419.
Application 17/511,419 is a division of application No. 15/906,645, filed on Feb. 27, 2018, granted, now 11,193,085.
Application 15/906,645 is a continuation of application No. PCT/JP2016/075445, filed on Aug. 31, 2016.
Claims priority of application No. 2015-170856 (JP), filed on Aug. 31, 2015.
Prior Publication US 2022/0049185 A1, Feb. 17, 2022
Int. Cl. C11C 1/04 (2006.01); A23D 9/007 (2006.01); A23L 33/12 (2016.01); A61K 31/201 (2006.01); A61K 31/202 (2006.01); C07C 51/087 (2006.01); C07C 57/12 (2006.01); C07C 69/58 (2006.01); C11C 3/00 (2006.01)
CPC C11C 1/04 (2013.01) [A23D 9/007 (2013.01); A23L 33/12 (2016.08); A61K 31/201 (2013.01); A61K 31/202 (2013.01); C07C 51/087 (2013.01); C07C 57/12 (2013.01); C07C 69/58 (2013.01); C11C 3/00 (2013.01); A23V 2002/00 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method of manufacturing a free polyunsaturated fatty acid-containing composition, the method comprising:
providing a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbons;
performing hydrolysis treatment on a reaction solution prepared by combining the provided raw material composition, a lower alcohol, water having an iron content of 0.01 ppm or less, and an alkali catalyst; and
after hydrolysis treatment, limiting contact between the reaction solution and any metal surface such that a product T (cm2·day), calculated by multiplying (i) the contact surface area (cm2) per 1 g of the reaction solution with the metal surface and (ii) a corresponding contact time (day) becomes 100 or less, does not exceed 100 cm2·day, thereby obtaining the free polyunsaturated fatty acid-containing composition.