US 12,110,336 B2
Method for treating a neurodegenerative disease by administering an anti-cellular prion protein (PrPc) antibody
Matthew Gardener, Cambridge (GB); Jayne Hammersley, Cambridge (GB); Maria Groves, Cambridge (GB); Gareth Rees, Cambridge (GB); Sadhana Podichetty, Cambridge (GB); and Andrew Billinton, Cambridge (GB)
Assigned to MedImmune Limited, Cambridge (GB)
Filed by MedImmune Limited, Cambridge (GB)
Filed on Sep. 14, 2020, as Appl. No. 17/020,247.
Application 17/020,247 is a division of application No. 16/093,687, granted, now 10,808,034, previously published as PCT/EP2017/058010, filed on Apr. 4, 2017.
Claims priority of provisional application 62/323,117, filed on Apr. 15, 2016.
Prior Publication US 2021/0070870 A1, Mar. 11, 2021
Int. Cl. C07K 16/28 (2006.01)
CPC C07K 16/2872 (2013.01) [C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/55 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] 2 Claims
 
1. A method for treating a neurodegenerative disorder in a subject in which aberrant PrPc activity is involved, comprising: administering to the subject a pharmaceutically effective amount of an antibody or an antigen-binding fragment comprising a light chain variable (VL) domain and a heavy chain variable (VH) domain, wherein the VH domain comprises:
a VH CDR 1 having the amino acid sequence of SEQ ID NO: 5;
a VH CDR2 having the amino acid sequence of SEQ ID NO: 6; and
a VH CDR3 having the amino acid sequence of SEQ ID NO: 7; and
the VL domain comprises:
a VL CDR1 having the amino acid sequence of SEQ ID NO: 14;
a VL CDR2 having the amino acid sequence of SEQ ID NO: 15; and
a VL CDR3 having the amino acid sequence of SEQ ID NO: 16; and
wherein the neurodegenerative disorder is one of: Alzheimer's Disease, disease associated with misfolded PrP, Creutzfeldt-Jakob Disease, Gerstmann-Sträussler-Schenker Disease, Fatal Familial Insomnia, bovine spongiform encephalopathy, scrapie, chronic wasting disease, transmissible mink encephalopathy, and feline spongiform encephalopathy.