US 12,110,329 B2
Anti-BTLA antibody
Hai Wu, Shanghai (CN); Jian Yao, Shanghai (CN); Sheng Yao, Shanghai (CN); Hui Feng, Shanghai (CN); Jing Zhang, Shanghai (CN); and Yuehua Zhou, Jiangsu (CN)
Assigned to Shanghai Junshi Biosciences Co., Ltd., Shanghai (CN); and Junmeng Biosciences Co., Ltd., Jiangsu (CN)
Filed by Shanghai Junshi Biosciences Co., Ltd., Shanghai (CN); and Junmeng Biosciences Co., Ltd., Jiangsu (CN)
Filed on Feb. 1, 2021, as Appl. No. 17/164,597.
Application 17/164,597 is a continuation in part of application No. PCT/CN2019/098150, filed on Jul. 29, 2019.
Claims priority of application No. 201810870514.0 (CN), filed on Aug. 2, 2018.
Prior Publication US 2021/0246209 A1, Aug. 12, 2021
Int. Cl. C07K 16/28 (2006.01); A61K 39/00 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01)
CPC C07K 16/2818 (2013.01) [A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); A61P 35/00 (2018.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] 15 Claims
 
1. An isolated anti-BTLA antibody or an antigen-binding fragment thereof wherein the amino acid sequences of the LCDR1, LCDR2 and LCDR3 of the light chain CDR and the amino acid sequences of the HCDR1, HCDR2 and HCDR3 of the heavy chain CDR of the isolated antibody or the antigen-binding fragment thereof are selected from any one of the following groups I-IX:
 
 
 
 Group LCDR1 LCDR2 LCDR3
 
 
 
 I SEQ ID NO: 7 SEQ ID NO: 8 SEQ ID NO: 9
 
 II SEQ ID NO: 10 SEQ ID NO: 11 SEQ ID NO: 12
 
 III SEQ ID NO: 16 SEQ ID NO: 17 SEQ ID NO: 18
 
 IV SEQ ID NO: 22 SEQ ID NO: 23 SEQ ID NO: 24
 
 V SEQ ID NO: 22 SEQ ID NO: 23 SEQ ID NO: 24
 
 VI SEQ ID NO: 31 SEQ ID NO: 32 SEQ ID NO: 33
 
 VII SEQ ID NO: 7 SEQ ID NO: 8 SEQ ID NO: 9
 
 VIII SEQ ID NO: 10 SEQ ID NO: 11 SEQ ID NO: 12
 
 IX SEQ ID NO: 10 SEQ ID NO: 11 SEQ ID NO: 12
 
 
 
 Group HCDR1 HCDR2 HCDR3
 
 
 
 I SEQ ID NO: 1 SEQ ID NO: 2 SEQ ID NO: 3
 
 II SEQ ID NO: 4 SEQ ID NO: 5 SEQ ID NO: 6
 
 III SEQ ID NO: 13 SEQ ID NO: 14 SEQ ID NO: 15
 
 IV SEQ ID NO: 19 SEQ ID NO: 20 SEQ ID NO: 21
 
 V SEQ ID NO: 25 SEQ ID NO: 26 SEQ ID NO: 27
 
 VI SEQ ID NO: 28 SEQ ID NO: 29 SEQ ID NO: 30
 
 VII SEQ ID NO: 4 SEQ ID NO: 5 SEQ ID NO: 6
 
 VIII SEQ ID NO: 1 SEQ ID NO: 2 SEQ ID NO: 3
 
 IX SEQ ID NO: 13 SEQ ID NO: 14 SEQ ID NO: 15.