	US 12,110,327 B2
	Anti-TREM1 antibodies and methods of use thereof
Andrew Pincetic, San Francisco, CA (US); Arnon Rosenthal, Woodside, CA (US); Helen Lam, South San Francisco, CA (US); Francesca Avogadri-Connors, South Hamilton, MA (US); and Seung-Joo Lee, Benicia, CA (US)
Assigned to Alector LLC, South San Francisco, CA (US)
Filed by Alector LLC, South San Francisco, CA (US)
Filed on Sep. 13, 2022, as Appl. No. 17/931,757.
Application 17/931,757 is a division of application No. 16/078,965, granted, now 11,472,877, previously published as PCT/US2017/020745, filed on Mar. 3, 2017.
Claims priority of provisional application 62/304,018, filed on Mar. 4, 2016.
Prior Publication US 2023/0121869 A1, Apr. 20, 2023
Int. Cl. C07K 16/28 (2006.01)

CPC C07K 16/2803 (2013.01) [C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/55 (2013.01); C07K 2317/73 (2013.01); C07K 2317/75 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01); C07K 2317/80 (2013.01); C07K 2317/92 (2013.01)]

22 Claims

1. An isolated antibody that binds to a TREM1 protein, comprising a heavy chain and a light chain, wherein the light chain comprises a hypervariable region L1 (HVR-L1) comprising the amino acid sequence of SEQ ID NO: 10, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 29, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 101, and wherein the heavy chain comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 130, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 159, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 229.