US 12,110,319 B2
Anti-yellow fever virus antibodies, and methods of their generation and use
Anna Wec, Lebanon, NH (US); and Laura Walker, Norwich, VT (US)
Assigned to Mabloc, LLC, Washington, DC (US)
Filed by Mabloc, LLC, Washington, DC (US)
Filed on Oct. 11, 2023, as Appl. No. 18/485,163.
Application 18/485,163 is a continuation of application No. 18/045,802, filed on Oct. 11, 2022, abandoned.
Application 18/045,802 is a continuation of application No. 17/103,844, filed on Nov. 24, 2020, granted, now 11,479,598.
Claims priority of provisional application 62/940,049, filed on Nov. 25, 2019.
Prior Publication US 2024/0218054 A1, Jul. 4, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/10 (2006.01); A61K 39/42 (2006.01); A61P 31/14 (2006.01)
CPC C07K 16/10 (2013.01) [A61K 39/42 (2013.01); A61P 31/14 (2018.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] 17 Claims
 
1. A method of treating or preventing a Yellow Fever Virus (YFV) infection or at least one symptom arising therefrom, comprising administering to a patient in need thereof or suspected of being in need thereof an isolated antibody or antigen-binding fragment thereof,
wherein the antibody or antigen-binding fragment thereof specifically binds to a YFV protein, wherein the antibody or antigen-binding fragment thereof comprises:
(i) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:307 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:459;
(ii) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:308 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:460;
(iii) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:311 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:463;
(iv) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:320 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:471; or
(v) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:341 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:492.