US 12,110,307 B2
Self-immolative systems
Andrew Russell, Reading (GB); Wayne Cord Hayes, Reading (GB); Mark Rodney Sambrook, Salisbury (GB); Flavien Leroux, Reading (GB); Aaron Acton, Reading (GB); Antonio Feula, Reading (GB); and Alexander Gabriel Gavriel, Reading (GB)
Assigned to The Secretary of State for Defence, Salisbury (GB)
Appl. No. 17/280,240
Filed by THE SECRETARY OF STATE FOR DEFENCE, Salisbury (GB)
PCT Filed Oct. 29, 2019, PCT No. PCT/GB2019/000150
§ 371(c)(1), (2) Date Mar. 26, 2021,
PCT Pub. No. WO2020/089571, PCT Pub. Date May 7, 2020.
Claims priority of application No. 1817730 (GB), filed on Oct. 30, 2018.
Prior Publication US 2021/0340166 A1, Nov. 4, 2021
Int. Cl. C07F 9/50 (2006.01); A62D 3/30 (2007.01); C07F 9/54 (2006.01); C07F 9/70 (2006.01); G01N 31/22 (2006.01)
CPC C07F 9/5031 (2013.01) [A62D 3/30 (2013.01); C07F 9/5022 (2013.01); C07F 9/5442 (2013.01); C07F 9/70 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A self-immolative molecule suitable to be triggered by non-protic electrophilic agents, having structural formula:

OG Complex Work Unit Chemistry
wherein Nu is phosphorus (P), R1 and R2 comprise phenyl functional groups or substituted phenyl functional groups, and releasable portion is a chemical moiety capable of generating a detection/measurable response upon release.