US 12,109,429 B2
Phototherapeutic light for treatment of pathogens
Nathan Stasko, Chapel Hill, NC (US); David T. Emerson, Durham, NC (US); Adam Cockrell, Durham, NC (US); F. Neal Hunter, Durham, NC (US); Michael John Bergmann, Atlanta, GA (US); Rebecca McDonald, Chapel Hill, NC (US); Nicholas William Medendorp, Jr., Raleigh, NC (US); Gerald H. Negley, Chapel Hill, NC (US); and Katelyn P. Reighard, Durham, NC (US)
Assigned to KNOW Bio, LLC, Morrisville, NC (US)
Filed by KNOW Bio, LLC, Durham, NC (US)
Filed on Dec. 10, 2020, as Appl. No. 17/117,858.
Application 17/117,858 is a continuation in part of application No. 16/898,385, filed on Jun. 10, 2020, granted, now 11,617,895.
Application 16/898,385 is a continuation of application No. 16/709,550, filed on Dec. 10, 2019, granted, now 11,524,173.
Application 16/709,550 is a continuation of application No. 15/222,199, filed on Jul. 28, 2016, granted, now 10,525,275.
Claims priority of provisional application 63/123,631, filed on Dec. 10, 2020.
Claims priority of provisional application 63/084,802, filed on Sep. 29, 2020.
Claims priority of provisional application 63/074,800, filed on Sep. 4, 2020.
Claims priority of provisional application 62/987,318, filed on Mar. 9, 2020.
Claims priority of provisional application 62/197,746, filed on Jul. 28, 2015.
Prior Publication US 2021/0128935 A1, May 6, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 5/06 (2006.01); H01L 27/15 (2006.01)
CPC A61N 5/0613 (2013.01) [A61N 5/0601 (2013.01); A61N 5/0603 (2013.01); A61N 5/0624 (2013.01); H01L 27/15 (2013.01); A61N 2005/0611 (2013.01); A61N 2005/0626 (2013.01); A61N 2005/0647 (2013.01); A61N 2005/0652 (2013.01); A61N 2005/0653 (2013.01); A61N 2005/0661 (2013.01); A61N 2005/0662 (2013.01); A61N 2005/0663 (2013.01)] 34 Claims
OG exemplary drawing
 
1. A method comprising:
providing a light source configured to emit light comprising a first light characteristic including a first peak wavelength in a range from 400 nanometers (nm) to 450 nm; and
irradiating mammalian tissue within a body with the light to induce a biological effect by administering a dose of light of no more than 50 joules per square centimeter (J/cm2) during a time period of no more than 10 minutes, and repeatably administering the dose of light a number of times to provide a cumulative dose in a range from greater than 50 J/cm2 to 1000 J/cm2 over a cumulative time period in a range from 1 day to 7 consecutive days, wherein the biological effect comprises altering a concentration of one or more pathogens within the body and altering growth of the one or more pathogens within the body.