US 12,109,412 B2
Combination electrical and chemotherapeutic treatment of cancer
Brian L. Schmidt, White Bear Lake, MN (US); Benjamin Keith Stein, Shoreview, MN (US); Keith R. Maile, New Brighton, MN (US); Ron A. Balczewski, Bloomington, MN (US); and Aleksandra Kharam, Maple Grove, MN (US)
Assigned to Boston Scientific Scimed, Inc., Maple Grove, MN (US)
Filed by Boston Scientific Scimed, Inc., Maple Grove, MN (US)
Filed on Apr. 16, 2020, as Appl. No. 16/850,728.
Claims priority of provisional application 62/837,130, filed on Apr. 22, 2019.
Prior Publication US 2020/0330758 A1, Oct. 22, 2020
Int. Cl. A61N 1/36 (2006.01); A61B 10/02 (2006.01); A61N 5/06 (2006.01); A61P 35/00 (2006.01)
CPC A61N 1/36002 (2017.08) [A61B 10/02 (2013.01); A61N 5/0601 (2013.01); A61P 35/00 (2018.01)] 13 Claims
OG exemplary drawing
 
1. A method for treating a cancerous tumor located within a subject comprising:
applying one or more electric fields at or near a site of the cancerous tumor, the cancerous tumor comprising a cancerous cell population;
wherein the one or more applied electric fields are effective to delay mitosis and cause mitotic synchronization within a proportion of the cancerous cell population;
receiving a pause command from the subject and/or a care provider, wherein the pause command causes cessation of the one or more electric fields to allow mitosis to proceed within the cancerous cell population;
reinitiating the one or more electric fields after a time period has elapsed after receiving the pause command, wherein the one or more electric fields is decreased by at least 50% for at least 4 hours; and
administering a chemotherapeutic agent to the subject after the one or more electric fields have been removed.