US 12,109,395 B2
Device and mixing and/or reconstitution method
Michael Schabbach, Frankfurt am Main (DE); Claus Geiger, Frankfurt am Main (DE); Andrea Heiberger, Frankfurt am Main (DE); Dieter Kadereit, Frankfurt am Main (DE); Charlotte Emma Harvey, Harston (GB); Congyi Huang, Cambridge (GB); Timothy Charles Frearson, Harston (GB); and Alexander David Norman, Harston (GB)
Assigned to Sanofi, Paris (FR); and Sagentia Ltd., Cambridge (GB)
Appl. No. 16/764,041
Filed by SANOFI, Paris (FR)
PCT Filed Nov. 15, 2018, PCT No. PCT/EP2018/081375
§ 371(c)(1), (2) Date May 14, 2020,
PCT Pub. No. WO2019/096908, PCT Pub. Date May 23, 2019.
Claims priority of application No. 17306598 (EP), filed on Nov. 17, 2017.
Prior Publication US 2020/0276388 A1, Sep. 3, 2020
Int. Cl. A61M 5/19 (2006.01); A61J 1/20 (2006.01); A61M 5/20 (2006.01); A61M 5/315 (2006.01)
CPC A61M 5/19 (2013.01) [A61J 1/201 (2015.05); A61J 1/2093 (2013.01); A61M 5/2066 (2013.01); A61M 5/31596 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A device comprising:
a housing;
a first chamber within the housing, wherein the first chamber contains a first material;
a second chamber containing a first piston and a second piston, wherein the first piston and the second piston are axially moveable within the second chamber; and
a second material initially contained within the second chamber between the first piston and the second piston,
wherein the device is adapted such that activation of the device causes movement of one of the first piston or the second piston in an axial direction of the device thereby
moving the other of the first piston and the second piston in the axial direction of the device,
opening a fluid communication path between the second chamber and the first chamber, and
expelling the second material from the second chamber into the first chamber via the fluid communication path, and
wherein the device further comprises a plunger which closes a proximal end of the first chamber within the housing, wherein the plunger contains the second chamber, wherein the plunger is axially moveable within the housing of the device, and wherein axial movement of the plunger within the housing activates the device and causes a pressure drop in the first chamber;
and wherein the plunger comprises a through-hole at its distal end closed by a plug, which is connected with the second piston.