US 12,109,334 B2
Three dimensional electrospun biomedical patch for facilitating tissue repair
Matthew R. MacEwan, St. Louis, MO (US)
Assigned to Washington University, St. Louis, MO (US)
Filed by Washington University, St. Louis, MO (US)
Filed on Jan. 25, 2023, as Appl. No. 18/159,412.
Application 16/131,887 is a division of application No. 14/429,976, granted, now 10,124,089, issued on Nov. 13, 2018, previously published as PCT/US2012/056548, filed on Sep. 21, 2012.
Application 18/159,412 is a continuation of application No. 17/576,058, filed on Jan. 14, 2022, granted, now 11,596,717.
Application 17/576,058 is a continuation of application No. 17/381,792, filed on Jul. 21, 2021, granted, now 11,253,635, issued on Feb. 22, 2022.
Application 17/381,792 is a continuation of application No. 17/229,226, filed on Apr. 13, 2021, granted, now 11,173,234, issued on Nov. 16, 2021.
Application 17/229,226 is a continuation of application No. 16/872,926, filed on May 12, 2020.
Application 16/872,926 is a continuation of application No. 16/540,779, filed on Aug. 14, 2019, granted, now 10,682,444, issued on Jun. 16, 2020.
Application 16/540,779 is a continuation of application No. 16/131,887, filed on Sep. 14, 2018, granted, now 10,441,685, issued on Oct. 15, 2019.
Prior Publication US 2023/0347023 A1, Nov. 2, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/18 (2006.01); A61F 13/02 (2006.01); A61L 15/26 (2006.01); A61L 15/44 (2006.01); A61L 15/64 (2006.01); A61L 27/26 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01); A61L 27/60 (2006.01); A61L 31/04 (2006.01); B29C 48/18 (2019.01); B32B 5/02 (2006.01); B32B 5/26 (2006.01); B32B 7/02 (2019.01); B32B 7/12 (2006.01); D01D 5/00 (2006.01); D04H 1/728 (2012.01); D04H 3/16 (2006.01)
CPC A61L 31/04 (2013.01) [A61L 15/26 (2013.01); A61L 15/44 (2013.01); A61L 15/64 (2013.01); A61L 27/18 (2013.01); A61L 27/54 (2013.01); A61L 27/58 (2013.01); A61L 27/60 (2013.01); B29C 48/18 (2019.02); B32B 5/022 (2013.01); B32B 5/26 (2013.01); B32B 7/02 (2013.01); B32B 7/12 (2013.01); D01D 5/0007 (2013.01); D01D 5/0038 (2013.01); D01D 5/0061 (2013.01); D01D 5/0076 (2013.01); D04H 1/728 (2013.01); D04H 3/16 (2013.01); A61F 13/02 (2013.01); A61L 2300/414 (2013.01); A61L 2400/12 (2013.01); A61L 2400/18 (2013.01); A61L 2430/20 (2013.01); A61L 2430/32 (2013.01); B32B 2250/20 (2013.01); B32B 2262/0276 (2013.01); B32B 2307/518 (2013.01); B32B 2307/54 (2013.01); B32B 2307/726 (2013.01); B32B 2307/7265 (2013.01); B32B 2556/00 (2013.01); D10B 2509/00 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A three-dimensional electrospun biomedical patch for facilitating tissue repair, the three-dimensional electrospun biomedical patch comprising:
a structure of bioresorbable deposited electrospun fibers generated by electrospinning a first polymer composition and a second polymer composition, the deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a period of time upon application of the three-dimensional electrospun biomedical patch to a tissue, wherein the period of time is less than twelve months, wherein the structure of deposited electrospun fibers comprise one or more high density fiber deposition areas and one or more low density fiber deposition areas, and the one or more high density fiber deposition areas and the one or more low density fiber deposition areas are entangled; and
a plurality of voids within the structure of bioresorbable deposited electrospun fibers, the plurality of voids comprising one or more voids between 10 μm and 10 cm in length,
wherein the three-dimensional electrospun biomedical patch is pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.