US 12,109,330 B2
Shapeable scaffold material and uses thereof
Amelie Barbara Hildegarde Beduer, Lausanne (CH); Thomas Braschler, Chavannes-Renens (CH); Philippe Renaud, Preverenges (CH); Giorgio Pietramaggiori, Lausanne (CH); and Saja Scherer, Lausanne (CH)
Assigned to Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne (CH)
Filed by Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne (CH)
Filed on Jan. 7, 2022, as Appl. No. 17/570,549.
Application 17/570,549 is a continuation of application No. 15/752,752, granted, now 11,219,703, previously published as PCT/IB2016/054947, filed on Aug. 18, 2016.
Claims priority of application No. 1514788 (GB), filed on Aug. 20, 2015.
Prior Publication US 2022/0313871 A1, Oct. 6, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/56 (2006.01); A61L 15/42 (2006.01); A61L 27/22 (2006.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); A61L 27/50 (2006.01); A61L 27/52 (2006.01)
CPC A61L 27/56 (2013.01) [A61L 27/227 (2013.01); A61L 27/3616 (2013.01); A61L 27/38 (2013.01); A61L 27/50 (2013.01); A61L 27/52 (2013.01); A61L 27/505 (2013.01)] 22 Claims
 
1. A scaffold material for use in manufacturing shapeable three-dimensional body implants, wherein:
the scaffold material consists essentially of a plurality of elastically compressible particles;
the particles have a plurality of interconnected pores in their core and on their surface that are connected to an environment external to the particles;
non-pore space of the particles is wall material;
the wall material comprises a macromolecular polymer gel constructed of a network of hydrogel forming materials;
the pores have a mean pore diameter between 1 μm and 2 mm;
the particles have a ratio of mean pore diameter to wall material thickness of at least 3; and
the scaffold material is a shapeable paste, or becomes a shapeable paste when contacted with a liquid, wherein the shapeable paste has a reversible compressibility volume ratio between a hydrated state and a dehydrated state of between 1.2 and 50.