US 12,109,270 B2
Rifaximin complexes
Maruti Ganpati Ghagare, Mumbai (IN); Sunilkumar Parasnath Saroj, Mumbai (IN); Dharmaraj Ramachandra Rao, Mumbai (IN); and Rajendra Narayanrao Kankan, Mumbai (IN)
Assigned to CIPLA LIMITED, Mumbai (IN)
Filed by CIPLA LIMITED, Mumbai (IN)
Filed on Jul. 12, 2022, as Appl. No. 17/862,491.
Application 17/862,491 is a continuation of application No. 16/440,219, filed on Jun. 13, 2019, abandoned.
Application 16/440,219 is a continuation of application No. 16/005,251, filed on Jun. 11, 2018, granted, now 10,328,153, issued on Jun. 25, 2019.
Application 16/005,251 is a continuation of application No. 14/521,292, filed on Oct. 22, 2014, granted, now 9,993,561, issued on Jun. 12, 2018.
Application 14/521,292 is a continuation of application No. 13/132,054, granted, now 8,916,193, issued on Dec. 23, 2014, previously published as PCT/GB2009/002854, filed on Dec. 9, 2009.
Claims priority of application No. 2577/MUM/2008 (IN), filed on Dec. 10, 2008.
Prior Publication US 2023/0181741 A1, Jun. 15, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/40 (2006.01); A61K 9/20 (2006.01); A61K 31/4184 (2006.01); A61K 31/437 (2006.01); A61K 47/32 (2006.01); A61K 47/58 (2017.01); A61K 47/69 (2017.01); B82Y 5/00 (2011.01)
CPC A61K 47/40 (2013.01) [A61K 9/2095 (2013.01); A61K 31/4184 (2013.01); A61K 31/437 (2013.01); A61K 47/32 (2013.01); A61K 47/58 (2017.08); A61K 47/6951 (2017.08); B82Y 5/00 (2013.01); Y02A 50/30 (2018.01)] 12 Claims
 
1. A method of treating bowel disorders, the method comprising:
administering to a patient a therapeutically effective amount of a complex comprising rifaximin and a complexing agent, wherein the complex is in an amorphous form and exhibits enhanced solubility compared to a physical mixture of rifaximin and the complexing agent.