	US 12,109,217 B2
	Bioactive agents included in functionalized starch having a single helix V-structure
Tien Canh Le, Montreal (CA); and Mircea-Alexandru Mateescu, Montreal (CA)
Assigned to B-Organic Films Corp., Montreal (CA)
Appl. No. 15/121,993
Filed by B-ORGANIC FILMS CORP., Montreal (CA)
PCT Filed Feb. 25, 2015, PCT No. PCT/CA2015/000117 § 371(c)(1), (2) Date Aug. 26, 2016, PCT Pub. No. WO2015/127537, PCT Pub. Date Sep. 3, 2015.
Claims priority of provisional application 61/945,495, filed on Feb. 27, 2014.
Prior Publication US 2017/0072069 A1, Mar. 16, 2017
Int. Cl. A61K 31/593 (2006.01); A01N 33/12 (2006.01); A23D 9/007 (2006.01); A23L 29/219 (2016.01); A23L 33/10 (2016.01); A23L 33/105 (2016.01); A23L 33/12 (2016.01); A23L 33/155 (2016.01); A23P 10/40 (2016.01); A61K 8/02 (2006.01); A61K 8/34 (2006.01); A61K 8/35 (2006.01); A61K 8/73 (2006.01); A61K 9/20 (2006.01); A61K 31/122 (2006.01); A61K 31/202 (2006.01); A61K 31/366 (2006.01); A61K 47/69 (2017.01); A61Q 5/02 (2006.01); A61Q 5/12 (2006.01); C08B 31/04 (2006.01); C08B 31/12 (2006.01); C08J 3/12 (2006.01); C08K 5/00 (2006.01); C08K 5/01 (2006.01); C08K 5/05 (2006.01); C08K 5/07 (2006.01); C08K 5/103 (2006.01); C08K 5/14 (2006.01)

CPC A61K 31/593 (2013.01) [A01N 33/12 (2013.01); A23D 9/007 (2013.01); A23L 29/219 (2016.08); A23L 33/10 (2016.08); A23L 33/105 (2016.08); A23L 33/12 (2016.08); A23L 33/155 (2016.08); A23P 10/40 (2016.08); A61K 8/022 (2013.01); A61K 8/347 (2013.01); A61K 8/35 (2013.01); A61K 8/732 (2013.01); A61K 9/2059 (2013.01); A61K 31/122 (2013.01); A61K 31/202 (2013.01); A61K 31/366 (2013.01); A61K 47/6949 (2017.08); A61Q 5/02 (2013.01); A61Q 5/12 (2013.01); C08B 31/04 (2013.01); C08B 31/12 (2013.01); C08J 3/12 (2013.01); C08K 5/0041 (2013.01); C08K 5/01 (2013.01); C08K 5/05 (2013.01); C08K 5/07 (2013.01); C08K 5/103 (2013.01); C08K 5/14 (2013.01); A61K 2800/56 (2013.01); C08J 2300/14 (2013.01); C08J 2303/04 (2013.01); Y02A 50/30 (2018.01)]

14 Claims

1. A powder composition comprising:

a carboxymethylated starch powder prepared by the following process:

(a) placing a native starch and sodium monochloroacetate (SMCA) in an alkaline solvent-water medium having a solvent:water ratio of from about 70% to about 95% (vol/vol) solvent in water and at least 3 M sodium hydroxide (NaOH), and stirring for at least 10 hours at a temperature of from about 22° C. to about 28° C. to generate a carboxymethylated starch; and

(b) washing and drying the carboxymethylated starch from step (a) to generate the carboxymethylated starch powder,

and

a poorly water-soluble or water insoluble bioactive agent, forming a water-soluble or water dispersible inclusion complex with said carboxymethylated starch powder,

wherein said carboxymethylated starch powder and said bioactive agent are present in a ratio of about 4:1 to about 1:1 w/w.