US 12,109,215 B2
Combination therapies for inhibition of polo-like kinase 4
Jacqueline M. Mason, Toronto (CA); Mark R. Bray, Oakville (CA); Tak Wah Mak, Toronto (CA); and Graham Fletcher, Toronto (CA)
Assigned to UNIVERSITY HEALTH NETWORK, Toronto (CA)
Appl. No. 16/644,633
Filed by UNIVERSITY HEALTH NETWORK, Toronto (CA)
PCT Filed Sep. 7, 2018, PCT No. PCT/CA2018/051086
§ 371(c)(1), (2) Date Mar. 5, 2020,
PCT Pub. No. WO2019/046949, PCT Pub. Date Mar. 14, 2019.
Claims priority of provisional application 62/555,718, filed on Sep. 8, 2017.
Prior Publication US 2021/0060026 A1, Mar. 4, 2021
Int. Cl. A61K 31/5377 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01)
CPC A61K 31/5377 (2013.01) [A61K 39/3955 (2013.01); A61P 35/00 (2018.01)] 8 Claims
OG exemplary drawing
 
1. A method for treating colon cancer, comprising:
administering to a subject an effective amount of a compound represented by the formula:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof and an effective amount of a PD-1 inhibitor.