	US 12,109,180 B2
	Articles with active agent concentrated at the substrate contacting surface and related methods
Anna Andrews, Wadsworth, OH (US); Rachel Shi, Lyndhurst, OH (US); Anne Marie Wibaux, Fontainebleau (FR); and Emily Berlin, Chicago, IL (US)
Assigned to Avery Dennison Corporation, Mentor, OH (US)
Filed by Avery Dennison Corporation, Mentor, OH (US)
Filed on Apr. 25, 2022, as Appl. No. 17/660,515.
Application 17/660,515 is a division of application No. 15/315,847, granted, now 11,337,940, previously published as PCT/US2015/034336, filed on Jun. 5, 2015.
Claims priority of provisional application 62/008,154, filed on Jun. 5, 2014.
Prior Publication US 2022/0249408 A1, Aug. 11, 2022
Int. Cl. A61K 31/155 (2006.01); A61K 9/70 (2006.01)

CPC A61K 31/155 (2013.01) [A61K 9/7007 (2013.01); A61K 9/7084 (2013.01)]

20 Claims

1. An adhesive article configured to deliver an active agent to a user's skin comprising:

a backing;

an adhesive layer disposed on the backing defining a skin contacting surface, the skin contacting surface being configured to bond the adhesive article to the user's skin; and

an active agent disposed on the skin contacting surface of the adhesive layer such that the active agent will be disposed between the user's skin and the skin contacting surface of the adhesive layer when the adhesive article is adhered to the user's skin,

wherein the active agent is mixed with a vehicle consisting of a non-aqueous liquid vehicle to thereby define a concentrated active adhesive, the concentrated active adhesive being disposed on the skin contacting surface of the adhesive layer; and wherein a portion of the adhesive layer is free of active agent dispersed therein.