US 12,109,151 B2
Process monitoring and control during laser-based refractive index modification of intraocular lenses in patients
Richard Hofer, Santa Cruz, CA (US); Alexander Vankov, Mountain View, CA (US); Jenny Wang, Mountain View, CA (US); David A. Dewey, Sunnyvale, CA (US); Phillip Gooding, Mountain View, CA (US); and Georg Schuele, Portola Valley, CA (US)
Assigned to AMO Development, LLC, Irvine, CA (US)
Filed by AMO Development, LLC, Irvine, CA (US)
Filed on Dec. 22, 2022, as Appl. No. 18/145,020.
Application 18/145,020 is a continuation of application No. 17/057,689, granted, now 11,540,946, previously published as PCT/IB2020/053327, filed on Apr. 7, 2020.
Claims priority of provisional application 62/925,185, filed on Oct. 23, 2019.
Claims priority of provisional application 62/832,797, filed on Apr. 11, 2019.
Prior Publication US 2023/0130142 A1, Apr. 27, 2023
Int. Cl. A61F 9/008 (2006.01); A61L 27/16 (2006.01); A61B 17/00 (2006.01)
CPC A61F 9/00827 (2013.01) [A61F 9/00834 (2013.01); A61L 27/16 (2013.01); A61B 2017/00061 (2013.01); A61B 2017/00154 (2013.01); A61F 2009/00844 (2013.01); A61F 2009/00851 (2013.01); A61F 2009/00897 (2013.01); A61L 2430/16 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A method for real-time process monitoring during laser-based refractive index modification of an intraocular lens (IOL), comprising:
treating the IOL with a laser beam to modify a refractive index of the IOL at selected locations, including scanning the laser beam in a predefined scan pattern in the IOL, the scan pattern includes at least one circular pattern;
while treating the IOL with the laser beam, measuring an image of a signal from the IOL, the signal being indicative of a refractive index change of the IOL;
determining a processing effect of refractive index modification of the IOL based on the measured image, including detecting at least one circular pattern of the signal in the measured image and detecting any non-uniformity of intensity of the signal in an angular direction along the circular pattern of the signal to determine a non-uniformity of the processing effect of the refractive index modification of the IOL in the angular direction; and
based on the detected non-uniformity of intensity, further treating the IOL with the laser beam to reduce or eliminate the non-uniformity of the processing effect of the refractive index modification of the IOL in the angular direction.