US 12,109,023 B2
Thermally stable glucose limiting membrane for glucose sensors
Jenn-Hann Larry Wang, Northridge, CA (US); Dero Hovanes, Glendale, CA (US); and Poonam S. Gulati, La Canada, CA (US)
Assigned to MEDTRONIC MINIMED, INC., Northridge, CA (US)
Filed by Medtronic MiniMed, Inc., Northridge, CA (US)
Filed on Jul. 11, 2023, as Appl. No. 18/350,482.
Application 18/350,482 is a division of application No. 17/477,944, filed on Sep. 17, 2021, granted, now 11,730,406.
Application 17/477,944 is a division of application No. 15/981,681, filed on May 16, 2018, granted, now 11,134,872, issued on Oct. 5, 2021.
Application 15/981,681 is a continuation in part of application No. 15/612,759, filed on Jun. 2, 2017, granted, now 11,179,078, issued on Nov. 23, 2021.
Claims priority of provisional application 62/346,301, filed on Jun. 6, 2016.
Prior Publication US 2023/0346274 A1, Nov. 2, 2023
Int. Cl. A61B 5/1486 (2006.01); A61B 5/00 (2006.01); A61B 5/145 (2006.01); C08G 18/32 (2006.01); C08G 18/40 (2006.01); C08G 18/44 (2006.01); C08G 18/50 (2006.01); C08G 18/61 (2006.01); C08G 18/72 (2006.01); C08G 18/73 (2006.01); C08G 18/76 (2006.01); C08L 75/12 (2006.01); C08G 77/448 (2006.01); C08G 77/458 (2006.01)
CPC A61B 5/14865 (2013.01) [A61B 5/14532 (2013.01); A61B 5/686 (2013.01); C08G 18/3228 (2013.01); C08G 18/4009 (2013.01); C08G 18/44 (2013.01); C08G 18/5024 (2013.01); C08G 18/61 (2013.01); C08G 18/72 (2013.01); C08G 18/724 (2013.01); C08G 18/73 (2013.01); C08G 18/7671 (2013.01); C08L 75/12 (2013.01); A61B 5/6876 (2013.01); A61B 2562/125 (2013.01); C08G 77/448 (2013.01); C08G 77/458 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A method of making an analyte sensor for implantation within a mammal comprising the steps of:
providing a base layer;
forming a conductive layer on the base layer, wherein the conductive layer includes a working electrode;
forming an analyte sensing layer on the conductive layer, wherein the analyte sensing layer includes an oxidoreductase;
forming an analyte modulating layer on the analyte sensing layer, wherein the analyte modulating layer:
(a) is formed by a reaction mixture comprising:
from 17% to 23% weight percent hexamethylene diisocyanate;
from 0% to 8.5% weight percent methylene diphenyl diisocyanate;
from 14% to 48% weight percent polydimethylsiloxane having amino terminal groups; and from 7.5% to 19% weight percent poly(1,6-hexyl carbonate) diol; and
a catalyst present in the reaction mixture in amounts less than 0.2% of reaction mixture components; and
(b) exhibits a greater thermal stability than a comparable analyte modulating layer formed from a reaction mixture where the catalyst is present in the formulation in amounts greater than or equal to 0.2% of the reaction mixture.