US 12,109,019 B2
Systems and methods for analyte detection
Alexander Yoshikawa, Redwood City, CA (US); Vijit Sabnis, Cupertino, CA (US); Pawan Kapur, San Mateo, CA (US); Vladimir Kesler, Palo Alto, CA (US); Donald A. Ice, Milpitas, CA (US); and George M. Mihalakis, San Jose, CA (US)
Assigned to Adaptyx Biosciences, Inc., Redwood City, CA (US)
Filed by Adaptyx Biosciences, Inc., Redwood City, CA (US)
Filed on Dec. 15, 2023, as Appl. No. 18/542,386.
Claims priority of provisional application 63/523,500, filed on Jun. 27, 2023.
Claims priority of provisional application 63/453,746, filed on Mar. 21, 2023.
Claims priority of provisional application 63/443,425, filed on Feb. 5, 2023.
Claims priority of provisional application 63/443,039, filed on Feb. 2, 2023.
Claims priority of provisional application 63/432,983, filed on Dec. 15, 2022.
Prior Publication US 2024/0197213 A1, Jun. 20, 2024
Int. Cl. A61B 5/145 (2006.01); A61B 5/00 (2006.01); A61B 5/1459 (2006.01)
CPC A61B 5/14546 (2013.01) [A61B 5/1459 (2013.01); A61B 5/685 (2013.01); A61B 5/725 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A device for sensing an analyte in a biological sample of a subject, comprising:
a support;
a piercing element coupled to the support, wherein the piercing element is configured to pierce a body surface of the subject when the device is coupled to the body surface to bring the piercing element in contact with the biological sample;
an analyte binding probe on or within the piercing element, wherein the analyte binding probe is configured to provide a change in an optical signal when the analyte binding probe comes in contact with the analyte in the biological sample of the subject;
a light source operatively coupled to the support;
a detector operatively coupled to the support, wherein the detector is configured to detect the optical signal;
a waveguide comprising an optical excitation path and an optical emission path,
wherein the waveguide is configured to transmit light from the light source to the analyte binding probe through the optical excitation path, and
wherein the waveguide is configured to transmit light through the optical emission path from the analyte binding probe towards the detector, and wherein the optical emission path further comprises apertures in a reflective cladding layer surrounding the waveguide configured to transmit an emission light from the analyte binding probe to the detector.