US 11,781,950 B2
Integrated dissolution processing and sample transfer system
Kevin Whitkanack, Stow, MA (US); Philip Gauthier, Worcester, MA (US); Robert Houser, North Attleboro, MA (US); Tye Fowler, Uxbridge, MA (US); and Ryan Kelly, Shirley, MA (US)
Assigned to SOTAX Corporation, Westborough, MA (US)
Filed by SOTAX Corporation, Westborough, MA (US)
Filed on Aug. 3, 2020, as Appl. No. 16/984,011.
Application 16/984,011 is a continuation of application No. 16/600,891, filed on Oct. 14, 2019, granted, now 10,732,080.
Prior Publication US 2021/0108992 A1, Apr. 15, 2021
Int. Cl. G01N 1/10 (2006.01); G01N 1/40 (2006.01); G01N 33/15 (2006.01); A61K 9/16 (2006.01); A61K 9/20 (2006.01)
CPC G01N 1/10 (2013.01) [G01N 1/4055 (2013.01); G01N 2001/4061 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A system for testing quality of a pharmaceutical dosage form, the system comprising:
a weight station configured to receive the pharmaceutical dosage form and to measure a weight of the pharmaceutical dosage form;
an extraction system configured to receive the pharmaceutical dosage form after the weight of the pharmaceutical dosage form is measured and to extract one or more ingredients of the pharmaceutical dosage form; and
an analysis module configured to receive a sample of a fluid containing the one or more ingredients extracted from the pharmaceutical dosage form and to perform spectral or chemical analysis of the sample,
wherein:
the extraction system comprises:
a cell having an inlet port and configured to receive through the inlet port the fluid containing the one or more ingredients of the pharmaceutical dosage form;
a heater configured to heat the fluid before entering the cell through the inlet port;
a first temperature sensor positioned between the heater and the inlet port, and configured to measure a first temperature of the fluid before entering the cell;
a second temperature sensor positioned in proximity of an output port of the cell and configured to measure a second temperature of the fluid after the fluid exits the cell through the output port;
a fluid reservoir configured to receive the fluid after the fluid exits the cell through the output port;
a closed loop circulation path between the fluid reservoir and the cell;
a pump facilitating circulation of the fluid between the fluid reservoir and the cell; and
a controller in communication with the heater, and further in communication with the first temperature sensor and the second temperature sensor, and configured to:
receive temperature data including the first temperature and the second temperature; and
control the heater based on a measured fluid temperature derived from the first temperature and the second temperature; and
the analysis module is configured to receive the sample of the fluid after the fluid exits the cell through the output port.