CPC C40B 30/06 (2013.01) [A61K 39/00115 (2018.08); A61K 2039/572 (2013.01); A61K 2039/80 (2018.08)] | 13 Claims |
1. A method of treating cancer in a subject, the method comprising:
administering a variable epitope library vaccine composition comprising one or more synthetic isolated peptides having amino acid sequences corresponding to an epitope of a tumor antigen that is essential for tumor survival and expressed by said tumor at high levels, or nucleic acid encoding said synthetic isolated peptides, said one or more peptides having from about 7 to about 50 total amino acids, wherein from about 1% to about 50% of the total amino acids of the one or more peptides are variable amino acids, and a pharmaceutically acceptable excipient; wherein the composition generates an immune response when administered to the subject, and wherein said cancer if present in said subject, has a mass of less than 10 mm2, wherein the tumor antigen is survivin comprising a CTL epitope, wherein the survivin CTL epitope is the peptide represented by GWEPDDNPI (SEQ ID NO: 2) having variable amino acids at positions 3, 5 and 7 (GWXPXDXPI (SEQ ID NO: 1)).
|