	US 11,780,933 B2
	HER3 antigen-binding molecules
Jerome Douglas Boyd-Kirkup, Singapore (SG); Piers Ingram, Singapore (SG); Dipti Thakkar, Singapore (SG); Zhihao Wu, Singapore (SG); Konrad Paszkiewicz, Singapore (SG); Vicente Sancenon, Singapore (SG); and Siyu Guan, Singapore (SG)
Assigned to Hummingbird Bioscience Pte. Ltd., Singapore (SG)
Filed by Hummingbird Bioscience Pte. Ltd., Singapore (SG)
Filed on Feb. 28, 2020, as Appl. No. 16/805,620.
Application 16/805,620 is a continuation of application No. 16/596,723, filed on Oct. 8, 2019, granted, now 10,662,241.
Application 16/596,723 is a continuation of application No. PCT/EP2019/058035, filed on Mar. 29, 2019.
Prior Publication US 2020/0308275 A1, Oct. 1, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/395 (2006.01); C07K 16/32 (2006.01); C07K 16/28 (2006.01); A61P 35/00 (2006.01); C07K 14/725 (2006.01); C12N 15/62 (2006.01); C12N 15/85 (2006.01); A61K 39/00 (2006.01)

CPC C07K 16/32 (2013.01) [A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 16/28 (2013.01); C12N 15/62 (2013.01); C12N 15/85 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/522 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/72 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01)]

13 Claims

1. An antigen-binding molecule comprising a heavy chain variable (VH) region and a light chain variable (VL) region, wherein the antigen-binding molecule specifically binds to HER3, wherein binding to HER3 comprises contact with one or more amino acid residues of the region of HER3 shown in SEQ ID NO:229, and wherein the antigen-binding molecule comprises:

a VH region incorporating the following CDRs:

HC-CDR1 having the amino acid sequence of SEQ ID NO:43

HC-CDR2 having the amino acid sequence of SEQ ID NO:46

HC-CDR3 having the amino acid sequence of SEQ ID NO:51; and

a VL region incorporating the following CDRs:

LC-CDR1 having the amino acid sequence of SEQ ID NO:91

LC-CDR2 having the amino acid sequence of SEQ ID NO:94

LC-CDR3 having the amino acid sequence of SEQ ID NO:99.