CPC C07H 1/00 (2013.01) [A61K 39/39 (2013.01); A61K 51/0491 (2013.01); C07H 21/02 (2013.01); A61K 2039/51 (2013.01); A61K 2039/53 (2013.01); A61K 2039/55505 (2013.01)] | 13 Claims |
1. A method for reducing thermal degradation of a RNA molecule, comprising the step of synthesising the RNA molecule in presence of deuterium to obtain a deuterium-stabilised RNA molecule incorporating deuterium, wherein the deuterium-stabilised RNA molecule incorporating deuterium comprises substitution of protium atoms by deuterium atoms, and wherein the deuterium-stabilised RNA molecule incorporating deuterium consists of a messenger RNA (mRNA) molecule.
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