US 11,780,869 B2
Deuterium-stabilised ribonucleic acid (RNA) molecules displaying increased resistance to thermal and enzymatic hydrolysis, aqueous compositions comprising stabilised RNA molecules and methods for making same
Pavel Gris, Collingwood (CA); and Alfred James Farmilo, Belleville (CA)
Assigned to deutraMed Solutions Ltd., Collingwood (CA)
Filed by deutraMed Solutions Ltd., Collingwood (CA)
Filed on Dec. 14, 2022, as Appl. No. 18/80,919.
Application 18/080,919 is a division of application No. 17/522,946, filed on Nov. 10, 2021, granted, now 11,566,038.
Claims priority of provisional application 63/114,418, filed on Nov. 16, 2020.
Claims priority of provisional application 63/112,370, filed on Nov. 11, 2020.
Prior Publication US 2023/0109802 A1, Apr. 13, 2023
Int. Cl. C07H 21/04 (2006.01); C07H 1/00 (2006.01); A61K 39/39 (2006.01); C07H 21/02 (2006.01); A61K 51/04 (2006.01); A61K 39/00 (2006.01)
CPC C07H 1/00 (2013.01) [A61K 39/39 (2013.01); A61K 51/0491 (2013.01); C07H 21/02 (2013.01); A61K 2039/51 (2013.01); A61K 2039/53 (2013.01); A61K 2039/55505 (2013.01)] 13 Claims
 
1. A method for reducing thermal degradation of a RNA molecule, comprising the step of synthesising the RNA molecule in presence of deuterium to obtain a deuterium-stabilised RNA molecule incorporating deuterium, wherein the deuterium-stabilised RNA molecule incorporating deuterium comprises substitution of protium atoms by deuterium atoms, and wherein the deuterium-stabilised RNA molecule incorporating deuterium consists of a messenger RNA (mRNA) molecule.