US 11,780,803 B2
Process for the preparation of cyclopropane compounds using diazo-compounds
Fridtjof Schröder, Hettlingen (CH); and Marcel Steck, Frauenfeld (CH)
Assigned to GIVAUDAN SA, Vernier (CH)
Appl. No. 16/973,591
Filed by Givaudan SA, Vernier (CH)
PCT Filed Jun. 25, 2019, PCT No. PCT/EP2019/066849
§ 371(c)(1), (2) Date Dec. 9, 2020,
PCT Pub. No. WO2020/002338, PCT Pub. Date Jan. 2, 2020.
Claims priority of application No. 1810514 (GB), filed on Jun. 27, 2018.
Prior Publication US 2021/0253514 A1, Aug. 19, 2021
Int. Cl. C07C 245/16 (2006.01); B01J 8/18 (2006.01); B01J 19/00 (2006.01); C07C 2/86 (2006.01)
CPC C07C 245/16 (2013.01) [B01J 8/1881 (2013.01); B01J 19/0093 (2013.01); C07C 2/86 (2013.01); B01J 2208/00858 (2013.01); B01J 2219/00867 (2013.01); B01J 2219/00889 (2013.01); C07C 2523/44 (2013.01); C07C 2601/02 (2017.05)] 19 Claims
 
1. A process for the continuous production of a reaction product of a diazo compound and a substrate in a multi-stage continuous flow reactor comprising at least two connected reactors in fluid communication with each other, wherein a reaction product formed at each stage of the multistage sequence is continuously discharged from an upstream reactor in which it is formed, and is fed as a continuous fluid stream into a downstream reactor whereupon it can undergo further conversion, the process being characterized in that a precursor compound of the diazo compound that is continuously formed in an upstream reactor is continuously discharged into a downstream reactor under conditions conducive to convert it into the diazo-compound, and wherein said downstream reactor contains the substrate with which the diazo-compound reacts to form the reaction product of the diazo compound and the substrate.