US 11,779,267 B2
Macro/micro-structure of sleep and similar states of consciousness to optimize pain treatment
Gary Nelson Garcia Molina, Madison, WI (US); Gaurav Trivedi, Pittsburgh, PA (US); and Gino Iasella, Pittsburgh, PA (US)
Assigned to KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Filed on Nov. 30, 2020, as Appl. No. 17/106,883.
Claims priority of provisional application 62/990,110, filed on Mar. 16, 2020.
Prior Publication US 2021/0282704 A1, Sep. 16, 2021
Int. Cl. A61B 5/00 (2006.01); A61B 5/0205 (2006.01); A61B 5/024 (2006.01); A61B 5/08 (2006.01); A61B 5/11 (2006.01); A61B 5/316 (2021.01); A61B 5/318 (2021.01); A61B 5/369 (2021.01); A61B 5/372 (2021.01); A61B 5/383 (2021.01); A61B 5/389 (2021.01); A61B 5/398 (2021.01); G16H 20/30 (2018.01); G16H 10/20 (2018.01); G16H 20/10 (2018.01); G16H 40/63 (2018.01); G16H 40/67 (2018.01); G01P 13/00 (2006.01); G16H 50/70 (2018.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01); G09B 19/00 (2006.01); A61B 5/1455 (2006.01); A61B 5/38 (2021.01); A61B 5/378 (2021.01)
CPC A61B 5/4818 (2013.01) [A61B 5/0205 (2013.01); A61B 5/02405 (2013.01); A61B 5/02416 (2013.01); A61B 5/08 (2013.01); A61B 5/1102 (2013.01); A61B 5/1118 (2013.01); A61B 5/316 (2021.01); A61B 5/318 (2021.01); A61B 5/369 (2021.01); A61B 5/372 (2021.01); A61B 5/383 (2021.01); A61B 5/389 (2021.01); A61B 5/398 (2021.01); A61B 5/4088 (2013.01); A61B 5/4809 (2013.01); A61B 5/4812 (2013.01); A61B 5/4815 (2013.01); A61B 5/4836 (2013.01); A61B 5/6801 (2013.01); A61B 5/6892 (2013.01); A61B 5/6898 (2013.01); A61B 5/7246 (2013.01); A61B 5/7264 (2013.01); A61B 5/7267 (2013.01); A61B 5/7278 (2013.01); G01P 13/00 (2013.01); G16H 10/20 (2018.01); G16H 20/10 (2018.01); G16H 20/30 (2018.01); G16H 40/63 (2018.01); G16H 40/67 (2018.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01); G16H 50/70 (2018.01); A61B 5/024 (2013.01); A61B 5/02438 (2013.01); A61B 5/0816 (2013.01); A61B 5/1103 (2013.01); A61B 5/1123 (2013.01); A61B 5/14552 (2013.01); A61B 5/378 (2021.01); A61B 5/38 (2021.01); A61B 5/6802 (2013.01); A61B 5/6891 (2013.01); G09B 19/00 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A method of optimization of a pain treatment in an individual, comprising:
during at least a portion a period of reduced consciousness of the individual, detecting a number of signals from a number of monitoring devices applied to the individual, wherein the detecting of the number of signals comprises receiving a cardiac input based at least in part upon at least one of an ECG signal from an ECG monitoring device and a PPG signal from a PPG monitoring device;
determining an index of pain in the individual based at least in part upon the number of signals, wherein the index of pain is based at least in part on: (i) a spectral ratio of alpha power to delta power during that at least a portion of the period of reduced consciousness, (ii) an index of heart-rate variability (HRV) obtained at least in part from the cardiac input, and (iii) an index comprising a linear combination of sleep latency (SL), a sleep efficiency (SE), and an average duration of a number of sleep bouts; and
causing a control actuator to
a pain treatment of the individual based at least in part on the index of pain.