CPC A01K 67/0276 (2013.01) [A01K 67/0278 (2013.01); A01K 2207/12 (2013.01); A01K 2217/075 (2013.01); A01K 2217/15 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01)] | 12 Claims |
1. An immunodeficient non-obese diabetic mouse whose genome comprises: (a) a homozygous scid mutation in the endogenous Prkdc gene; (b) a homozygous null mutation in the endogenous Il2rg gene; (c) a homozygous null mutation in the endogenous H2-K1 gene; (d) a homozygous null mutation in the endogenous H2-D1 gene; and (e) a homozygous null mutation in the endogenous H2-Ab1 gene; wherein the genotype of the mouse is NOD.Cg-Prkdcscid H2-K1tm1Bpe H2-Ab1em1Mvw H2-D1tm1Bpe Il2rgtm1Wjl/SzJ, and the mouse lacks functional major histocompatibility complex (MHC) I, lacks functional MHC II, and has a human immunoglobulin G (IgG) clearance rate of no more than 60% two days after administration of human IgG to the mouse.
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