US 12,437,980 B2
Mass spectrometry retrieving of stray samples
Mohit Jain, San Diego, CA (US); Saumya Tiwari, San Diego, CA (US); and Jeramie Watrous, San Diego, CA (US)
Assigned to Sapient Bioanalytics, LLC, San Diego, CA (US)
Filed by Sapient Bioanalytics, LLC, San Diego, CA (US)
Filed on May 20, 2022, as Appl. No. 17/750,254.
Prior Publication US 2023/0377863 A1, Nov. 23, 2023
Int. Cl. H01J 49/00 (2006.01)
CPC H01J 49/0036 (2013.01) 20 Claims
OG exemplary drawing
 
1. A computer-implemented method, comprising:
obtaining raw mass spectrometry data from samples;
generating an image representation from the raw mass spectrometry data, wherein the image representation indicates frequencies of local peaks from the samples;
selecting a portion of signals corresponding to the image representation;
obtaining retention time windows that include each signal of the portion of the signals;
generating windowed plots that capture each of the retention time windows;
determining whether to expand each of the retention time windows, wherein expanding of the retention time windows comprises obtaining offset plots that are offset from each of the windowed plots, wherein the determining of whether to expand the retention time windows is based on a presence or absence of an additional local peak signal, wherein the additional local peak signal is absent from a corresponding windowed plot;
in response to determining to expand a particular retention time window:
selectively expanding the particular retention time window based on the determination; and
retrieving information within an expanded particular retention time window; and
in response to determining not to expand the particular retention time window:
retrieving information within an unexpanded particular retention time window;
obtaining, from the retrieved information, one or more constituents or potential constituents of the samples; and
selectively performing a medical treatment based on the one or more constituents, wherein the medical treatment comprises restoring a level of the one or more constituents to a normal level.