US 12,436,160 B2
Method of detecting an obstruction in a fluid analyzer
Wei Zhang, Needham, MA (US)
Assigned to Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US)
Appl. No. 19/103,927
Filed by Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US)
PCT Filed Aug. 15, 2023, PCT No. PCT/US2023/072211
§ 371(c)(1), (2) Date Feb. 14, 2025,
PCT Pub. No. WO2024/040052, PCT Pub. Date Feb. 22, 2024.
Claims priority of provisional application 63/371,943, filed on Aug. 19, 2022.
Prior Publication US 2025/0258187 A1, Aug. 14, 2025
Int. Cl. G01N 35/00 (2006.01); G01N 35/10 (2006.01)
CPC G01N 35/00613 (2013.01) [G01N 35/00693 (2013.01); G01N 35/1004 (2013.01); G01N 35/1016 (2013.01)] 24 Claims
OG exemplary drawing
 
1. A fluid analyzer, comprising:
a fluid channel operable to carry fluids;
a sensor in fluidic communication with the fluid channel;
a meter operable to receive signals generated by the sensor and transform the signals into information indicative of an electric potential of the fluids;
a first calibration fluid having a first analyte concentration;
a second calibration fluid having a second analyte concentration different from the first analyte concentration;
one or more calibration fluid injection ports in fluidic communication with the fluid channel, the one or more calibration fluid injection ports being operable to receive a first calibration fluid and a second calibration fluid;
one or more valves positioned between the one or more calibration fluid injection ports and the sensor, the one or more valves being openable and closeable to provide one or more samples of each of the first calibration fluid and the second calibration fluid to the fluid channel; and
a control system having a processor operable to execute processor-executable code that when executed by the processor causes the processor to run an obstruction detection algorithm comprising:
at a first time period, controlling the one or more valves to successively pass the first calibration fluid and the second calibration fluid through the fluid channel to the sensor, and storing first data indicative of a first response slope based at least in part on a first difference between first information generated by the meter indicative of a first electric potential generated by the sensor contacting the first calibration fluid and second information indicative of a second electric potential generated by the sensor contacting the second calibration fluid;
at a second time period after the first time period, controlling the one or more valves to successively pass the first calibration fluid and the second calibration fluid through the fluid channel to the sensor, and storing second data indicative of a second response slope based at least in part on a second difference between third information indicative of a third electric potential generated by the sensor contacting the first calibration fluid and fourth information generated by the meter indicative of a fourth electric potential generated by the sensor contacting the second calibration fluid; and
storing third data indicative of an obstruction on the sensor in response to a difference between the first response slope and the second response slope being beyond a threshold.