US 12,436,157 B2
Analysis method, analysis device, analysis system, and analysis program for analyzing a bleeding tendency of a subject
Satomi Nishikawa, Kobe (JP)
Assigned to SYSMEX CORPORATION, Kobe (JP)
Filed by SYSMEX CORPORATION, Kobe (JP)
Filed on Mar. 18, 2022, as Appl. No. 17/698,144.
Claims priority of application No. 2021-046534 (JP), filed on Mar. 19, 2021.
Prior Publication US 2022/0299534 A1, Sep. 22, 2022
Int. Cl. G01N 33/86 (2006.01)
CPC G01N 33/86 (2013.01) [G01N 2458/15 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A blood coagulation analyzer configured to analyze a bleeding tendency of a subject, comprising:
a measuring device comprising:
a sample preparator configured to prepare a blood sample containing plasma, coagulation time measuring reagent, and coagulation activation reagent,
a holder configured to hold a container through which light passes, the container held in the holder containing the blood sample that has started a coagulation reaction,
a light source configured to irradiate to the blood sample in the container held in the holder, and
a detector configured to detect light from the blood sample irradiated by the light source and output signals corresponding to the detected light; and
a controller programed to:
obtain a time-series data set of the coagulation reaction of the blood sample based on the signals outputted from the detector;
obtain, based on the time-series data set, a maximum speed arrival time from a start of the coagulation reaction until a coagulation reaction speed is maximized or a maximum acceleration arrival time from the start of the coagulation reaction until a coagulation reaction acceleration is maximized, and a reference time in the coagulation reaction, the reference time being a time from the start of the coagulation reaction until the blood sample reaches a predetermined coagulation state;
obtain a value(S) based on the maximum speed arrival time or the maximum acceleration arrival time, and the reference time, wherein the value(S) is a first difference between the maximum speed arrival time and the reference time, a second difference between the maximum acceleration arrival time and the reference time, a first product of the first difference and a coefficient, or a second product of the second difference and the coefficient, the coefficient being based on a first absolute value of a coagulation reaction speed at the maximum speed arrival time from the start of the coagulation reaction, or a second absolute value of the coagulation reaction acceleration at the maximum acceleration arrival time from the start of the coagulation reaction; and
output information relating to the bleeding tendency based on the value(S), the information including a label indicating a degree of the bleeding tendency according to the value(S).