	US 12,435,335 B2
	Promoting nutrient absorption through the colon
Qiao Joe Zhou, Ardsley, NY (US)
Assigned to Cornell University, Ithaca, NY (US)
Filed by Cornell University, Ithaca, NY (US)
Filed on Sep. 26, 2022, as Appl. No. 17/935,492.
Claims priority of provisional application 63/349,436, filed on Jun. 6, 2022.
Prior Publication US 2023/0392145 A1, Dec. 7, 2023
Int. Cl. C12N 15/113 (2010.01); A61P 1/14 (2006.01); C12N 9/22 (2006.01); C12N 15/90 (2006.01)

CPC C12N 15/113 (2013.01) [A61P 1/14 (2018.01); C12N 9/22 (2013.01); C12N 15/907 (2013.01); C12N 2310/14 (2013.01); C12N 2310/20 (2017.05); C12N 2310/531 (2013.01); C12N 2800/80 (2013.01)]

20 Claims

1. A method comprising deleting or inactivating at least one Satb2 allele or inhibiting expression of a Satb2 gene in one or more starting cells of a subject, to thereby convert the starting cells into ileal-like cells, wherein the starting cells comprise colonic cells, colonic stem cells, colonic organoids, colonic progenitor cells or a combination thereof.