US 12,435,330 B2
Methods and compositions for prime editing RNA
David R. Liu, Cambridge, MA (US); Andrew Vito Anzalone, Cambridge, MA (US); James William Nelson, Cambridge, MA (US); and Peter J. Chen, Cambridge, MA (US)
Assigned to The Broad Institute, Inc., Cambridge, MA (US); and President and Fellows of Harvard College, Cambridge, MA (US)
Appl. No. 17/767,777
Filed by The Broad Institute, Inc., Cambridge, MA (US); and President and Fellows of Harvard College, Cambridge, MA (US)
PCT Filed Oct. 9, 2020, PCT No. PCT/US2020/055156
§ 371(c)(1), (2) Date Apr. 8, 2022,
PCT Pub. No. WO2021/072328, PCT Pub. Date Apr. 15, 2021.
Claims priority of provisional application 62/913,480, filed on Oct. 10, 2019.
Prior Publication US 2024/0417715 A1, Dec. 19, 2024
Int. Cl. C12N 15/10 (2006.01); C12N 9/12 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01)
CPC C12N 15/102 (2013.01) [C12N 9/127 (2013.01); C12N 9/22 (2013.01); C12N 15/111 (2013.01); C07K 2319/85 (2013.01); C12N 2310/20 (2017.05); C12Y 207/07048 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A fusion protein comprising a nucleic acid-programmable RNA binding protein and an RNA-dependent RNA polymerase.