US 12,435,321 B2
CRISPR/Cas12J enzyme and system
Jinsheng Lai, Beijing (CN); Yingsi Zhou, Beijing (CN); Yingnan Li, Beijing (CN); Jihong Zhang, Beijing (CN); Yingying Wang, Beijing (CN); Menglu Lyu, Beijing (CN); Xiangbo Zhang, Beijing (CN); Haiming Zhao, Beijing (CN); and Weibin Song, Beijing (CN)
Assigned to China Agricultural University, Beijing (CN)
Appl. No. 17/294,175
Filed by China Agricultural University, Beijing (CN)
PCT Filed Nov. 15, 2019, PCT No. PCT/CN2019/118702
§ 371(c)(1), (2) Date May 14, 2021,
PCT Pub. No. WO2020/098772, PCT Pub. Date May 22, 2020.
Claims priority of application No. 201811355943.0 (CN), filed on Nov. 15, 2018.
Prior Publication US 2022/0002691 A1, Jan. 6, 2022
Int. Cl. C12N 9/22 (2006.01); A61K 31/7088 (2006.01); A61K 38/46 (2006.01); A61K 47/62 (2017.01); A61K 48/00 (2006.01); C12N 15/11 (2006.01); C12N 15/90 (2006.01)
CPC C12N 9/22 (2013.01) [A61K 31/7088 (2013.01); A61K 38/465 (2013.01); A61K 47/62 (2017.08); C12N 15/11 (2013.01); C12N 15/907 (2013.01); A61K 48/00 (2013.01); C07K 2319/00 (2013.01); C12N 2310/20 (2017.05); C12N 2800/80 (2013.01)] 29 Claims
 
1. A protein, or a polynucleotide encoding the protein, where in the protein comprises an amino acid sequence of any one of SEQ ID NOs: 17, 2, or 20 with one or more amino acid substitutions, deletions or additions, and of at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity compared to a full-length sequence of any one of SEQ ID NOs: 17, 2, or 20.