US 12,435,307 B2
Neural tissue unit and use of such a unit for implantation into the nervous system of a mammal
Maxime Feyeux, Talence (FR); Kevin Allessandri, Bordeaux (FR); Pierre Nassoy, Bordeaux (FR); Laurent Cognet, Bordeaux (FR); Abdelhamid Benazzouz, Pessac (FR); and Erwan Bezard, Bordeaux (FR)
Assigned to UNIVERSITE DE BORDEAUX, Bordeaux (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); and INSTITUT D'OPTIQUE THEORIQUE ET APPLIQUEE, Palaiseau (FR)
Filed by UNIVERSITE DE BORDEAUX, Bordeaux (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); and INSTITUT D'OPTIQUE THEORIQUE ET APPLIQUEE, Palaiseau (FR)
Filed on Mar. 22, 2023, as Appl. No. 18/124,921.
Application 18/124,921 is a continuation of application No. 16/462,965, previously published as PCT/FR2017/053226, filed on Nov. 23, 2017.
Claims priority of application No. 1661378 (FR), filed on Nov. 23, 2016.
Prior Publication US 2023/0257699 A1, Aug. 17, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 5/0793 (2010.01); A61K 35/30 (2015.01); C12N 5/00 (2006.01)
CPC C12N 5/0619 (2013.01) [A61K 35/30 (2013.01); C12N 5/0012 (2013.01); C12N 2501/39 (2013.01); C12N 2501/42 (2013.01); C12N 2506/45 (2013.01)] 30 Claims
 
1. A neural tissue unit for use in cell therapy, wherein the neural tissue unit is implantable in the nervous system of a human or non-human mammal, wherein said neural tissue unit contains differentiated post-mitotic neuronal cells, having a phenotype of interest corresponding to the phenotype of defective cells to be replaced, and glial cells, said post-mitotic neuronal cells and glial cells being organized in a three-dimensional array in an extracellular matrix, said unit being obtained from a cellular microcompartment comprising a hydrogel capsule surrounding a single neural tissue unit, said differentiated post-mitotic neuronal cells having been obtained from mammalian pluripotent stem cells differentiated into post-mitotic neuronal cells within said hydrogel capsule and said hydrogel capsule being at least partially removed prior to use of said neural tissue unit.