US 12,435,306 B2
Method for setting up an apparatus for biological processes and apparatus for biological processes
Roland Mertelsmann, Freiburg (DE); Justus Duyster, Freiburg (DE); Marie Follo, Heitersheim (DE); Sascha Lange, Gundelfingen (DE); and Maximiliano S. Perez, Buenos Aires (AR)
Assigned to BIOTHERA INSTITUT GMBH, Freiburg (DE)
Appl. No. 17/260,369
Filed by BioThera Institut GmbH, Freiburg (DE)
PCT Filed Jul. 16, 2019, PCT No. PCT/EP2019/069115
§ 371(c)(1), (2) Date Jan. 14, 2021,
PCT Pub. No. WO2020/016223, PCT Pub. Date Jan. 23, 2020.
Claims priority of application No. 10 2018 117 395.4 (DE), filed on Jul. 18, 2018.
Prior Publication US 2021/0269762 A1, Sep. 2, 2021
Int. Cl. C12M 1/36 (2006.01); C12M 3/06 (2006.01); C12Q 3/00 (2006.01); G06F 7/58 (2006.01); G06N 5/04 (2023.01); G06N 20/00 (2019.01)
CPC C12M 41/48 (2013.01) [C12M 23/16 (2013.01); C12Q 3/00 (2013.01); G06F 7/58 (2013.01); G06N 5/04 (2013.01); G06N 20/00 (2019.01)] 12 Claims
 
1. A method for setting up an apparatus for biological processes, the apparatus comprising:
a vessel for accommodating a biological sample, with which a plurality of biological processes can be carried out;
adjustment means for adjusting process parameters for the biological processes;
capturing means comprising at least one of an imaging camera or a sensor, with which a process state is automatically capturable for each of the plurality of biological processes; and
a processor which is connected via a first data line to the capturing means and which is connected via a second data line to the adjustment means, and
the method comprising:
specifying, by the processor, the process parameters for the plurality of biological processes,
automatically capturing, by the capturing means, a process state for each of the plurality of biological processes;
evaluating, by the processor and based on a specified objective forming or derived from an evaluation criterion comprising at least one of a reward function, a cost function, or a penalty function, each automatically captured process state to generate an evaluated process state;
generating, by the processor and using a machine learning method which learns from evaluations of captured process states, learned set-up parameters based on the evaluated process states, wherein the learned set-up parameters comprise
(i) learned process parameters, or
(ii) assignments between captured process states and learned process parameters; and
setting up, by the processor and using the adjustment means, the apparatus based on the generated learned set-up parameters.