US 12,435,303 B2
Continuous flow reactor for low pH viral inactivation
Stephanie Parker, Rialto, CA (US); Cameron Lee Bardliving, Claremont, CA (US); Jonathan Coffman, Gaithersbury, CA (US); Scott Godfrey, Pleasanton, CA (US); and Raquel Orozco, Richmond, CA (US)
Assigned to Boehringer Ingelheim International GmbH, Ingelheim am Rhein (DE)
Appl. No. 17/283,281
Filed by Boehringer Ingelheim International GmbH, Ingelheim am Rhein (DE)
PCT Filed Oct. 7, 2019, PCT No. PCT/US2019/054959
§ 371(c)(1), (2) Date Apr. 7, 2021,
PCT Pub. No. WO2020/076681, PCT Pub. Date Apr. 16, 2020.
Claims priority of provisional application 62/742,534, filed on Oct. 8, 2018.
Prior Publication US 2021/0380914 A1, Dec. 9, 2021
Int. Cl. C12M 1/12 (2006.01); C12M 1/00 (2006.01); C12N 7/00 (2006.01)
CPC C12M 23/06 (2013.01) [C12M 47/12 (2013.01); C12N 7/00 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A viral inactivation device comprising:
at least one continuous viral inactivation reactor including an inlet, an outlet, and a tubular flow path comprising a set of alternating turns that form a serpentine pattern between the inlet and the outlet;
wherein the tubular flow path includes a diameter of from 0.6 cm to 0.7 cm;
and
wherein the set of alternating turns are segmented vertically into at least two stacked layers, wherein each of the at least two stacked layers include a thickness of from 0.7 cm to 1.2 cm.