US 12,435,268 B2
RNA fluorescent probe for rapidly distinguishing cancer tissue from normal tissue based on nucleolar morphological changes
Xiaoqiang Yu, Jinan (CN); Peng Gao, Jinan (CN); Xiuquan He, Jinan (CN); Fangfang Meng, Jinan (CN); Junyi He, Jinan (CN); and Zhiqiang Liu, Jinan (CN)
Assigned to SHANDONG UNIVERSITY, Jinan (CN)
Appl. No. 17/606,271
Filed by SHANDONG UNIVERSITY, Shandong (CN)
PCT Filed Dec. 3, 2020, PCT No. PCT/CN2020/133634
§ 371(c)(1), (2) Date Oct. 25, 2021,
PCT Pub. No. WO2022/016770, PCT Pub. Date Jan. 27, 2022.
Claims priority of application No. 202010711275.1 (CN), filed on Jul. 22, 2020.
Prior Publication US 2022/0325173 A1, Oct. 13, 2022
Int. Cl. C09K 11/06 (2006.01); C07D 401/06 (2006.01); G01N 1/30 (2006.01); G01N 21/64 (2006.01); G01N 33/58 (2006.01)
CPC C09K 11/06 (2013.01) [C07D 401/06 (2013.01); G01N 1/30 (2013.01); G01N 21/6428 (2013.01); G01N 33/582 (2013.01); C09K 2211/1018 (2013.01); G01N 2001/302 (2013.01); G01N 2021/6439 (2013.01)] 10 Claims
OG exemplary drawing
 
1. An RNA fluorescent probe for rapidly distinguishing cancer tissue from normal tissue, wherein a chemical name of the RNA fluorescent probe is (E)-1-(3-aminopropyl)-4-(2-(3-(9-ethyl-carbazol))vinyl)pyridine dibromide salt, abbreviated as CAPY-AP; a chemical structure of the RNA fluorescent probe is shown in formula (I):

OG Complex Work Unit Chemistry