US 12,435,188 B2
Method for preparing biodegradable polymer microparticles, and biodegradable polymer microparticles prepared thereby
Jin Su Kim, Yongin-si (KR); Wang Soo Shin, Daejeon (KR); and Na Jeong Park, Suwon-si (KR)
Assigned to SAMYANG HOLDINGS CORPORATION, Seoul (KR)
Appl. No. 16/633,727
Filed by SAMYANG HOLDINGS CORPORATION, Seoul (KR)
PCT Filed Jul. 25, 2018, PCT No. PCT/KR2018/008411
§ 371(c)(1), (2) Date Jan. 24, 2020,
PCT Pub. No. WO2019/022502, PCT Pub. Date Jan. 31, 2019.
Claims priority of application No. 10-2017-0095425 (KR), filed on Jul. 27, 2017.
Prior Publication US 2020/0207930 A1, Jul. 2, 2020
Int. Cl. C08J 3/12 (2006.01); A61K 9/16 (2006.01); A61L 27/18 (2006.01); A61L 27/20 (2006.01); A61L 27/26 (2006.01); A61L 27/58 (2006.01)
CPC C08J 3/12 (2013.01) [A61K 9/1647 (2013.01); A61K 9/1652 (2013.01); A61L 27/18 (2013.01); A61L 27/20 (2013.01); A61L 27/26 (2013.01); A61L 27/58 (2013.01); A61L 2300/604 (2013.01); C08J 2367/04 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A method for preparing porous biodegradable polymer microparticles, the method comprising the steps of:
1) dissolving a biodegradable polymer and a porogen in an organic solvent to form a dispersed phase;
2) applying pressure to the dispersed phase formed in step 1) to allow the dispersed phase to pass through the pore of SPG membrane (Shirasu Porous Glass membrane), and thereby to form an emulsion in a continuous phase comprising a surfactant; and
3) removing the organic solvent from the emulsion formed in step 2) to form porous microparticles,
wherein the biodegradable polymer is one or more selected from the group consisting of poly(glycolic acid), poly(caprolactone), derivatives thereof and copolymers thereof; and
the porous biodegradable polymer microparticles satisfy the following features i) to iii):
i) spherical shape;
ii) particle diameter of 20 to 40 μm;
iii) porosity ratio of 5 to 50%,
wherein the biodegradable polymer has a number average molecular weight (Mn) in a range of 10,000 to 100,000 g/mol,
wherein the SPG membrane has pores ranging from 10 to 30 μm, and
wherein the porous biodegradable polymer microparticles are suitable for preparing polymer filler for tissue repair.