	US 12,435,129 B2
	Anti-Aβ antibodies
Michael Skov, Belmont, CA (US); Tarlochan S. Nijjar, Orinda, CA (US); Sridhar Govindarajan, Los Altos, CA (US); Tom Purcell, Mountain View, CA (US); Mark Welch, Fremont, CA (US); Frédérique Bard, Pacifica, CA (US); Robin Barbour, Walnut Creek, CA (US); and Wagner Zago, San Carlos, CA (US)
Assigned to OTHAIR PROTHENA LIMITED, Dublin (IE)
Filed by OTHAIR PROTHENA LIMITED, Dublin (IE)
Filed on Jul. 23, 2021, as Appl. No. 17/383,765.
Claims priority of provisional application 63/219,611, filed on Jul. 8, 2021.
Claims priority of provisional application 63/187,379, filed on May 11, 2021.
Claims priority of provisional application 63/086,589, filed on Oct. 1, 2020.
Claims priority of provisional application 63/055,813, filed on Jul. 23, 2020.
Prior Publication US 2022/0049009 A1, Feb. 17, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/18 (2006.01); C07K 16/28 (2006.01); C07K 16/46 (2006.01); A61K 39/00 (2006.01)

CPC C07K 16/18 (2013.01) [C07K 16/2887 (2013.01); C07K 16/2896 (2013.01); C07K 16/462 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/34 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01); C07K 2317/92 (2013.01); C07K 2319/02 (2013.01); C07K 2319/30 (2013.01); C07K 2319/40 (2013.01)]

14 Claims

1. A nucleic acid encoding a heavy chain variable region and a light chain variable region of an antibody or fragment thereof that specifically binds to Aβ peptide, wherein the heavy chain variable region comprises heavy chain CDR1, CDR2, and CDR3 and the light chain variable region comprises light chain CDR1, CDR2, and CDR3, wherein the heavy chain CDR1, CDR2, and CDR3 and the light chain CDR1, CDR2, and CDR3 are SEQ ID NO: 19 (HCDR1), SEQ ID NO: 21 (HCDR2), and SEQ ID NO: 24 (HCDR3) and SEQ ID NO: 29 (LCDR1), SEQ ID NO: 34 (LCDR2), and SEQ ID NO: 38 (LCDR3).