US 12,435,118 B2
Chimeric antigen receptor and natural killer cells expressing same
Yu Kyeong Hwang, Yongin-si (KR); Sung Yoo Cho, Yongin-si (KR); Sung Yong Won, Yongin-si (KR); Ho Yong Lim, Yongin-si (KR); Jung Hyun Her, Yongin-si (KR); Mi Young Jung, Yongin-si (KR); Hyun Ah Kim, Yongin-si (KR); Su Hyun Gwon, Yongin-si (KR); Eun Sol Lee, Yongin-si (KR); and Han Sol Kim, Yongin-si (KR)
Assigned to GC Cell Corporation, Gyeonggi-do (KR)
Filed by GC Cell Corporation, Yongin-si (KR)
Filed on Jun. 21, 2022, as Appl. No. 17/845,793.
Application 17/845,793 is a continuation of application No. 16/474,426, abandoned, previously published as PCT/KR2017/015635, filed on Dec. 28, 2017.
Claims priority of application No. 1020160181119 (KR), filed on Dec. 28, 2016.
Prior Publication US 2023/0025506 A1, Jan. 26, 2023
Int. Cl. C07K 14/725 (2006.01); A61K 40/15 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01)
CPC C07K 14/7051 (2013.01) [A61K 40/15 (2025.01); A61K 40/31 (2025.01); A61K 40/4221 (2025.01); A61K 40/4224 (2025.01); C07K 16/2815 (2013.01); C07K 16/2818 (2013.01); C07K 16/283 (2013.01); C07K 16/2851 (2013.01); C12N 5/0646 (2013.01); A61K 2239/22 (2023.05); A61K 2239/48 (2023.05); A61K 2239/49 (2023.05); A61K 2239/55 (2023.05); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2319/03 (2013.01); C07K 2319/33 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A chimeric antigen receptor comprising, in order:
(A) an intracellular signaling domain comprising;
(i) a first domain comprising the amino acid sequence of SEQ ID NO:14; and
(ii) a second domain comprising the amino acid sequence of SEQ ID NO: 17;
(B) a transmembrane domain;
(C) a hinge domain; and
(D) an extracellular domain,
wherein the second domain is between the first domain and the transmembrane domain.