US 12,435,104 B2
Cyclic dinucleotides as sting agonists
Jing Li, Beijing (CN); Zhiwei Wang, Beijing (CN); Lina Gu, Beijing (CN); and Sanjia Xu, Beijing (CN)
Assigned to BeiGene, Ltd., Grand Cayman (KY)
Appl. No. 17/629,466
Filed by BEIGENE, LTD., Grand Cayman (KY)
PCT Filed Jul. 24, 2020, PCT No. PCT/CN2020/103987
§ 371(c)(1), (2) Date Jan. 24, 2022,
PCT Pub. No. WO2021/013234, PCT Pub. Date Jan. 28, 2021.
Claims priority of application No. PCT/CN2019/097644 (WO), filed on Jul. 25, 2019.
Prior Publication US 2022/0251135 A1, Aug. 11, 2022
Int. Cl. C07H 21/02 (2006.01)
CPC C07H 21/02 (2013.01) 15 Claims
 
1. A compound of formula (I):

OG Complex Work Unit Chemistry
or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof,
wherein:
R is selected from halogen, —C1-8alkyl, or —ORa, wherein Ra is hydrogen or —C1-8alkyl;
R1 and R2 are F;
X1 and X2, which are the same or different, are each independently O or S; and
Base1 and Base2, which are the same or different, are each independently

OG Complex Work Unit Chemistry