	US 12,435,094 B1
	Methods of preparing isomers, analogs, and synthetic derivatives from akuamma seeds
Haywood Max Mitchell, Santa Barbara, CA (US); Cecil Page, Ojai, CA (US); and Joseph William Merino, Oxnard, CA (US)
Filed by Haywood Max Mitchell, Santa Barbara, CA (US); Cecil Page, Ojai, CA (US); and Joseph William Merino, Oxnard, CA (US)
Filed on Nov. 12, 2024, as Appl. No. 18/945,335.
Int. Cl. C07D 491/22 (2006.01); B01D 11/02 (2006.01); B01D 11/04 (2006.01)

CPC C07D 491/22 (2013.01) [B01D 11/0203 (2013.01); B01D 11/0211 (2013.01); B01D 11/0265 (2013.01); B01D 11/028 (2013.01); B01D 11/0288 (2013.01); B01D 11/0296 (2013.01); B01D 11/0488 (2013.01); B01D 11/0492 (2013.01)]

15 Claims

1. A method for producing a synthetic compound from alkaloids obtained from akuamma, comprising:

dissolving a predetermined amount of powdered akuamma in a solvent under an argon atmosphere to form a first solution;

subjecting the first solution to an extraction process to recover a first extract possessing the alkaloids from the akuamma;

concentrating the first extract to obtain a second extract;

purifying the second extract using liquid-liquid extraction to obtain a third extract;

isolating the alkaloids from the third extract;

collecting the alkaloids; and

converting the alkaloids to the synthetic compound by a reaction selected from deprotonation, oxidation, alkylation, acylation, halogenation, or ring modification reactions.