	US 12,435,092 B2
	Substituted imidazo[1,2-A]quinazolines as inhibitors of PARG
James M. Veal, Solana Beach, CA (US); Jeffrey A. Stafford, Rancho Santa Fe, CA (US); Donald S. Karanewsky, Escondido, CA (US); and Shyama Herath, San Diego, CA (US)
Assigned to 858 THERAPEUTICS, INC., San Diego, CA (US)
Filed by 858 Therapeutics, Inc., San Diego, CA (US)
Filed on Feb. 14, 2024, as Appl. No. 18/441,757.
Application 18/441,757 is a continuation of application No. 18/199,900, filed on May 19, 2023, granted, now 11,939,335.
Application 18/199,900 is a continuation of application No. PCT/US2023/022390, filed on May 16, 2023.
Claims priority of provisional application 63/343,005, filed on May 17, 2022.
Prior Publication US 2024/0352018 A1, Oct. 24, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/519 (2006.01); C07D 487/04 (2006.01); C07D 487/14 (2006.01); C07D 491/147 (2006.01); C07D 491/20 (2006.01); C07D 519/00 (2006.01)

CPC C07D 487/04 (2013.01) [C07D 491/147 (2013.01); C07D 491/20 (2013.01); C07D 519/00 (2013.01); C07B 2200/05 (2013.01)]

20 Claims

1. A compound selected from the group consisting of:

(R)-4-((1-(2-hydroxyethyl)-1H-pyrazol-4-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)—N-(1-cyanocyclopropyl)-1-methyl-4-((1-methyl-1 H-pyrazol-4-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-(cyclopropylmethyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-4-(pyridin-3-ylmethyl)-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-4-((5-methyl-1H-pyrazol-3-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-((1H-pyrazol-4-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

4-((1-methyl-1H-pyrazol-3-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-((3,5-dimethylisoxazol-4-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-ethynyl-N-(1-methylcyclopropyl)-4-((3-methylisoxazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-ethynyl-N-(1-methylcyclopropyl)-4-((3-methylisoxazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-isopropyl-N-(1-methylcyclopropyl)-4-((3-methylisoxazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-isopropyl-N-(1-methylcyclopropyl)-4-((3-methylisoxazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-4-((3,5-dimethylisoxazol-4-yl)methyl)-1-ethyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-((3,5-dimethylisoxazol-4-yl)methyl)-1-ethyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-ethynyl-N-(1-methylcyclopropyl)-4-((2-methylthiazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-ethynyl-N-(1-methylcyclopropyl)-4-((2-methylthiazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-cyclopropyl-N-(1-methylcyclopropyl)-4-((2-methylthiazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-cyclopropyl-N-(1-methylcyclopropyl)-4-((2-methylthiazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-isopropyl-N-(1-methylcyclopropyl)-4-((2-methylthiazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-isopropyl-N-(1-methylcyclopropyl)-4-((2-methylthiazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-cyclopropyl-N-(1-methylcyclopropyl)-4-((3-methylisoxazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-cyclopropyl-N-(1-methylcyclopropyl)-4-((3-methylisoxazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-ethyl-N-(1-methylcyclopropyl)-4-((3-methylisoxazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-ethyl-N-(1-methylcyclopropyl)-4-((3-methylisoxazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-cyclopropyl-4-ethyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-cyclopropyl-4-ethyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-4-ethyl-1-ethynyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-ethyl-1-ethynyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-ethyl-N-(1-methylcyclopropyl)-4-((2-methylthiazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-ethyl-N-(1-methylcyclopropyl)-4-((2-methylthiazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-N-(1-methylcyclopropyl)-4-((2-methylthiazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-N-(1-methylcyclopropyl)-4-((3-methylisoxazol-5-yl)methyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-ethynyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-ethynyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-cyclopropyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-cyclopropyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-4-ethyl-1-isopropyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-ethyl-1-isopropyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-isopropyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-isopropyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1,4-diethyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1,4-diethyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

1-ethynyl-4-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-ethyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-ethyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-ethyl-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

1-cyclopropyl-4-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

1-isopropyl-4-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

1-ethyl-4-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-benzyl-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1,4-dimethyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-((1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-N-(1-methylcyclopropyl)-4-(oxetan-3-ylmethyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-4-((1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-4-((5-methyl-1,3,4-thiadiazol-2-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-((1-(difluoromethyl)-1H-pyrazol-4-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-4-(prop-2-yn-1-yl)-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1-(prop-1-yn-1-yl)-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1-(prop-1-yn-1-yl)-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl-d2)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-((3,5-dimethylisoxazol-4-yl)methyl-d2)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-N-(1-methylcyclopropyl)-4-((2-methylthiazol-5-yl)methyl-d2)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

2,2-dimethyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-trifluoromethyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-4-((1-cyanomethyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-((3,5-dimethylisoxazol-4-yl)methyl)-1-isopropyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-4-((3,5-dimethylisoxazol-4-yl)methyl)-1-isopropyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-cyclopropyl-4-((3,5-dimethylisoxazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-cyclopropyl-4-((3,5-dimethylisoxazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-((3,5-dimethylisoxazol-4-yl)methyl)-1-ethynyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-4-((3,5-dimethylisoxazol-4-yl)methyl)-1-ethynyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-((2,4-dimethylthiazol-5-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-8-fluoro-1-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-methyl-5-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-6-oxo-2,3,5,6-tetrahydro-1H-pyrimido[1,2-a]quinazoline-8-sulfonamide;

(R)-1-methyl-5-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-6-oxo-2,3,5,6-tetrahydro-1H-pyrimido[1,2-a]quinazoline-8-sulfonamide;

(S)-1-(methoxymethyl)-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-(methoxymethyl)-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(7aS,10aR)-6-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-6,7a,8,9,10,10a-hexahydro-5H-cyclopenta[4,5]imidazo[1,2-a]quinazoline-3-sulfonamide;

(R)-4-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-((1,5-dimethyl-1H-pyrazol-4-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-4-(cyclopropylmethyl)-1-(2,4-dimethylthiazol-5-yl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-(cyclopropylethynyl)-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-(cyclopropylethynyl)-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(7aS,10aR)-6-(dideutero(1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-6,7a,8,9,10,10a-hexahydro-5H-cyclopenta[4,5]imidazo[1,2-a]quinazoline-3-sulfonamide;

(R)-4-(dideutero(1-methyl-1H-pyrazol-4-yl)methyl)-8-fluoro-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-4-(dideutero(1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1-(trifluoromethyl)-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(7aS,10aR)—N-(1-cyanocyclopropyl)-6-(dideutero(1-methyl-1H-pyrazol-4-yl)methyl)-5-oxo-6,7a,8,9,10,10a-hexahydro-5H-cyclopenta[4,5]imidazo[1,2-a]quinazoline-3-sulfonamide;

(R)-4-(dideutero(2,4-dimethylthiazol-5-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-4-((1-methyl-1H-1,2,3-triazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-4-(dideutero(1-methyl-1H-pyrazol-4-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-(dideutero(1-methyl-1H-pyrazol-4-yl)methyl)-9-methoxy-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(7aR,10aS)-6-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-5,6,7a,8,10,10a-hexahydrofuro[3′,4′:4,5]imidazo[1,2-a]quinazoline-3-sulfonamide;

(R)—N-cyclopropyl-4-((2,4-dimethylthiazol-5-yl)methyl)-1-methyl-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-((dimethylamino)methyl)-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1-((dimethylamino)methyl)-4-((1-methyl-1 H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-(aminomethyl)-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(7aR,10aS)-6-(dideutero(2,4-dimethylthiazol-5-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-5,6,7a,8,10,10a-hexahydrofuro[3′,4′:4,5]imidazo[1,2-a]quinazoline-3-sulfonamide;

(R)-4-((1-methyl-1H-pyrazol-4-yl)methyl)-1-((methylamino)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

4′-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5′-oxo-4′,5′-dihydro-1′H-spiro[cyclopropane-1,2′-imidazo[1,2-a]quinazoline]-7′-sulfonamide;

4′-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5′-oxo-4′,5′-dihydro-1′H-spiro[cyclobutane-1,2′-imidazo[1,2-a]quinazoline]-7′-sulfonamide;

3,3-difluoro-4′-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5′-oxo-4′,5′-dihydro-1′H-spiro[cyclobutane-1,2′-imidazo[1,2-a]quinazoline]-7′-sulfonamide;

4′-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5′-oxo-4,4′,5,5′-tetrahydro-1′H,2H-spiro[furan-3,2′-imidazo[1,2-a]quinazoline]-7′-sulfonamide;

4′-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5′-oxo-4′,5′-dihydro-2′H-spiro[cyclobutane-1,1′-imidazo[1,2-a]quinazoline]-7′-sulfonamide;

4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-4,5-dihydro-2H-spiro[imidazo[1,2-a]quinazoline-1,3′-oxetane]-7-sulfonamide;

(S)-2-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-2-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(1R,2S)-1,2-dimethyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(1R,2R)-1,2-dimethyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(S)-1,2,2-trimethyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1,2,2-trimethyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-4-((2-methyl-1H-imidazol-5-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-(dideutero(2,4-dimethylthiazol-5-yl)methyl)-8-fluoro-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-4-(1-(1-methyl-1H-pyrazol-4-yl)cyclopropyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-((1,4-dimethyl-1H-imidazol-5-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-4,5-dihydro-1H-spiro[imidazo[1,2-a]quinazoline-2,3′-oxetane]-7-sulfonamide;

2-ethyl-2-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-((5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-((6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-3-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-((2,4-dimethyl-1H-imidazol-5-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-4-((4-methyl-1,2,3-thiadiazol-5-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-4-(dideutero(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-4-((1-methyl-5-oxopyrrolidin-3-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-9-chloro-1-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-4-((1-(1-methyl-1H-pyrazol-4-yl)ethyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

2-(methoxymethyl)-2-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-9-chloro-4-(dideutero(1-methyl-1H-pyrazol-4-yl)methyl)-1-methyl-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-9-bromo-1-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)—N,N-dimethyl-4-(1-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-7-(N-(1-methylcyclopropyl)sulfamoyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazolin-9-yl)piperazine-1-carboxamide;

(R)-1-methyl-9-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1,9-dimethyl-4-((1-methyl-1H-pyrazol-4-yl)methyl-d2)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-9-(3,6-dihydro-2H-pyran-4-yl)-1-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-1-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl-d2)-N-(1-methylcyclopropyl)-5-oxo-9-(trifluoromethyl)-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-9-(6-fluoropyridin-3-yl)-1-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-9-(4-fluorophenyl)-1-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide;

(R)-9-bromo-1-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl-d2)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide; and

(R)-9-cyano-1-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide,

or a pharmaceutically acceptable salt or deuteroisotope thereof.

2. The compound of claim 1, wherein the compound is (R)-1-methyl-4-((1-methyl-1H-pyrazol-4-yl)methyl)-N-(1-methylcyclopropyl)-5-oxo-1,2,4,5-tetrahydroimidazo[1,2-a]quinazoline-7-sulfonamide, or a pharmaceutically acceptable salt or deuteroisotope thereof.