US 12,435,069 B2
Cocrystals of posaconazole, methods of making and using same
Naír Rodriguez-Hornedo, Ann Arbor, MI (US); Gislaine Kuminek, Ann Arbor, MI (US); and Katie L. Cavanagh, Ann Arbor, MI (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US)
Appl. No. 17/629,899
Filed by REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US)
PCT Filed Jul. 31, 2020, PCT No. PCT/US2020/044374
§ 371(c)(1), (2) Date Jan. 25, 2022,
PCT Pub. No. WO2021/022103, PCT Pub. Date Feb. 4, 2021.
Claims priority of provisional application 62/881,043, filed on Jul. 31, 2019.
Prior Publication US 2022/0259189 A1, Aug. 18, 2022
Int. Cl. C07D 405/14 (2006.01)
CPC C07D 405/14 (2013.01) [C07B 2200/13 (2013.01)] 6 Claims
OG exemplary drawing
 
1. A cocrystal comprising posaconazole and a coformer, wherein the coformer comprises 4-aminobenzoic acid (4ABA), characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 5.8, 10.3, 11.5, 18.9, 19.3, 21.7, 22.4±0.2° 2θ using Cu Kα radiation.