US 12,435,064 B2
Quencher and uses thereof
Tae Young Kim, Cheongju-si (KR); Goutam Masanta, Cheongju-si (KR); Do Min Lee, Cheongju-si (KR); Ju Man Song, Cheongju-si (KR); and Jong Tae Je, Cheongju-si (KR)
Assigned to SFC CO., LTD., Cheongju-si (KR)
Filed by SFC CO., LTD., Cheongju-si (KR)
Filed on May 18, 2022, as Appl. No. 17/747,863.
Application 17/747,863 is a continuation of application No. PCT/KR2020/015592, filed on Nov. 9, 2020.
Claims priority of application No. 10-2019-0148348 (KR), filed on Nov. 19, 2019; and application No. 10-2020-0144159 (KR), filed on Nov. 2, 2020.
Prior Publication US 2022/0274960 A1, Sep. 1, 2022
Int. Cl. C07D 403/06 (2006.01); C07D 403/14 (2006.01)
CPC C07D 403/06 (2013.01) [C07D 403/14 (2013.01)] 14 Claims
 
1. A quencher represented by Formula 1 below:

OG Complex Work Unit Chemistry
wherein
R1 and R2 are each conjugated with a and b, b and c, or c and d of Formula 2 below,

OG Complex Work Unit Chemistry
Ar1 is selected from substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, and Formula 2,
n is an integer of 1 to 3, and
R3 to R19 are each independently selected from a functional group selected from hydrogen, deuterium, substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C1-C10 heteroalkyl containing at least one hetero atom, substituted or unsubstituted C2-C10 alkenyl, substituted or unsubstituted C2-C10 alkynyl, substituted or unsubstituted C3-C20 cycloalkyl, substituted or unsubstituted C1-C10 alkoxy, substituted or unsubstituted aryloxy, substituted or unsubstituted C1-C10 haloalkyl, a halogen, cyano, hydroxy, substituted or unsubstituted amino, substituted or unsubstituted amide, carbamate, sulfhydryl, nitro, carboxyl, carboxylate, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, quaternary ammonium, phosphoric acid, phosphate, substituted ketone, aldehyde, substituted ester, substituted sulfonyl, substituted or unsubstituted sulfonamide, acyl chloride, sulfonic acid, sulfonate, hydrazine, thiol, acetal, ketal, phosphonate (phosphite), hypophosphite, sulfohydroxy, sulfate, azido, guanidium, ketene, thiocarbonyl, aminothiocarbonyl, polyalkyleneoxide, a carboxyl derivative, dienophile, sulfonyl halide, epoxide, and phosphoramidite; and a reactive group capable of covalent bonding with a functional group selected from carboxyl, a carboxyl derivative, hydroxyl, haloalkyl, dienophile, aldehyde, ketone, sulfonyl halide, thiol, amine, sulfhydryl, alkene, epoxide, and phosphoramidite,
R5 and R6 are each independently present or connected to form a ring,
R7 and R8 are each independently present or connected to form a ring,
R18 and R19 are each independently present or connected to form a ring, and
L1 and L3 are linkers including a single bond or 1 to 40 non-hydrogen atoms, and L2 and L4 are linkers including 1 to 40 non-hydrogen atoms.