US 12,435,061 B2
Compounds and compositions for use in treating skin disorders
Xinyuan Wu, Newton, MA (US); Bertrand L. Chenard, Waterford, CT (US); Nili Claudia Schutz, Ness Ziona (IL); and Dov Terkieltaub, Herzliya (IL)
Assigned to KAMARI PHARMA LTD., Ness Ziona (IL)
Filed by Kamari Pharma Ltd., Ness Ziona (IL)
Filed on Apr. 13, 2023, as Appl. No. 18/300,234.
Application 18/300,234 is a continuation of application No. 17/160,802, filed on Jan. 28, 2021, granted, now 11,807,621.
Claims priority of provisional application 62/967,500, filed on Jan. 29, 2020.
Prior Publication US 2024/0124413 A1, Apr. 18, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 401/12 (2006.01); A61P 17/12 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 403/06 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 417/06 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01)
CPC C07D 401/12 (2013.01) [A61P 17/12 (2018.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 417/06 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01)] 44 Claims
 
1. A compound of formula (XXXII):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt, racemate, or stereoisomer thereof,
wherein;
G is pyridinyl pyrazinyl, or thiazolyl;
A is

OG Complex Work Unit Chemistry
 wherein* is bond to E or pyrrolidinyl ring of formula XXXII);
E is phenyl or pyrazinyl;
each R1 is independently cyano, nitro, hydroxy, halo, C1-C3 haloalkyl, C1-C3 haloalkoxy, C1-C6 alkyl, C1-C6 alkoxy, ether, aryl, —N(Ra)(Rb), —C(O) Rc, —CO2Rc, —C(O)N(Ra)(Rb), —SO2N(Ra)(Rb), or —SORc,
or two R1 groups together form a ring system;
each R2 and R3 is independently cyano, nitro, hydroxy, halo, C1-C3 haloalkyl, C1-C3 haloalkoxy, C1-C6 alkyl, hydroxyalkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, aryl, —N(Ra)(Rb), —C(O)Rc, —CH2Rc, —CO2Rc, —C(O)N(Ra)(Rb), —SO2N(Ra)(Rb), or —SORc; each Ra and Rb is independently H, hydroxyl, —ORc, C1-C6 alkyl, —C(O)Rc, or —C(O)ORc; each Rc is independently H, C1-C6 alkyl, or aryl;
n is 0, 1, or 2; p is 1, or 2; and q is 0, 1, or 2.